The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01108-0
Abstract: The gut-brain axis (GBA) is broadly accepted to describe the bidirectional circuit that links the gastrointestinal tract with the central nervous system (CNS). Interest in the GBA has grown dramatically over past two decades along… read more here.
Keywords: visceral hyperalgesia; hyperalgesia; brain axis; epigenomic regulatory ... See more keywords
G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-1000-3
Abstract: Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the… read more here.
Keywords: chronic hyperalgesia; inflammatory hyperalgesia; hyperalgesia; threshold regulator ... See more keywords
Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0780-3
Abstract: Our previous study has proposed that increased presynaptic NMDARs activities play pivotal roles in the development of opioid tolerance and hyperalgesia, and blocking spinal NMDARs attenuates chronic morphine-induced synaptic plasticity and behavior. However, the cellular… read more here.
Keywords: morphine induced; tolerance; tolerance hyperalgesia; hyperalgesia ... See more keywords
A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience bulletin"
DOI: 10.1007/s12264-021-00652-5
Abstract: Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C (TMEM16C)/Slack is required… read more here.
Keywords: remifentanil; hyperalgesia; slack; remifentanil induced ... See more keywords
The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.040
Abstract: BACKGROUND Functional dyspepsia (FD) is a common gastrointestinal disorder associated with persistent or recurrent upper gastrointestinal tract symptoms such as pain without any obvious pathological changes. Psychological and psychiatric factors might have a pathogenic role… read more here.
Keywords: corticotropin releasing; hyperalgesia; gastric hyperalgesia; crf2 ... See more keywords
The focus of spatial attention during the induction of central sensitization can modulate the subsequent development of secondary hyperalgesia
Sign Up to like & getrecommendations! Published in 2020 at "Cortex"
DOI: 10.1016/j.cortex.2019.11.014
Abstract: Intense or sustained activation of peripheral nociceptors can induce central sensitization. This enhanced responsiveness to nociceptive input of the central nervous system primarily manifests as an increased sensitivity to painful mechanical pinprick stimuli extending beyond… read more here.
Keywords: spatial attention; secondary hyperalgesia; central sensitization; hyperalgesia ... See more keywords
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134802
Abstract: BACKGROUND Neuroinflammation in the spinal cord is a pathological event in remifentanil-induced hyperalgesia (RIH), but its underlying molecular mechanisms remain unclear. Recent studies recapitulate the significance of the intracellular protease caspase-6 in the release of… read more here.
Keywords: caspase; spinal caspase; ccl21 cxcr3; hyperalgesia ... See more keywords
Social defeat stress-induced hyperalgesia is mediated by nav 1.8+ nociceptive fibers
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135006
Abstract: Recently the voltage-gated sodium (Nav) channels began to be studied as possible targets for analgesic drugs. In addition, specific Nav 1.8 blockers are currently being used to treat some types of chronic pain pathologies such… read more here.
Keywords: social defeat; nociceptive fibers; hyperalgesia; defeat stress ... See more keywords
ERK potentiates p38 in central sensitization induced by traumatic occlusion
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.11.012
Abstract: This study was to investigate the role of p38 activation via ERK1/2 phosphorylation in neurons and microglia of the spinal trigeminal subnucleus caudalis (Vc) in the promotion of orofacial hyperalgesia induced by unilateral anterior crossbite… read more here.
Keywords: central sensitization; hyperalgesia; p38; traumatic occlusion ... See more keywords
Toward understanding the opioid paradox: cellular mechanisms of opioid-induced hyperalgesia
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-021-01215-y
Abstract: The opioid epidemic is a major societal problem that has led to reevaluation of opioids as the mainstream treatment for chronic pain. Reports estimate that millions of people misuse opioids on an annual basis, particularly… read more here.
Keywords: latent sensitization; administration; response; hyperalgesia ... See more keywords
The opposing contribution of neurotrophin-3 and nerve growth factor to orofacial heat hyperalgesia in rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000503
Abstract: Supplemental Digital Content is available in the text. It has been proposed that neurotrophin-3 acts in a manner that is opposed to nerve growth factor, especially in the modulation of heat hyperalgesia. Injury to the… read more here.
Keywords: heat; heat hyperalgesia; growth factor; hyperalgesia ... See more keywords