Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pacemaker
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15476
Abstract: Patients with cirrhosis exhibit features of circadian disruption. Hyperammonaemia has been suggested to impair both homeostatic and circadian sleep regulation. Here, we tested if hyperammonaemia directly disrupts circadian rhythm generation in the central pacemaker, the… read more here.
Keywords: hyperammonaemia; glutamate; hyperammonaemia disrupts; disrupts daily ... See more keywords
The S1PR2‐CCL2‐BDNF‐TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12799
Abstract: Chronic hyperammonaemia and inflammation synergistically induce neurological impairment, including motor incoordination, in hepatic encephalopathy. Hyperammonaemic rats show neuroinflammation in the cerebellum which enhances GABAergic neurotransmission leading to motor incoordination. We aimed to identify underlying mechanisms.… read more here.
Keywords: hyperammonaemia; hyperammonaemic rats; s1pr2 ccl2; motor ... See more keywords
‘All that glitters is not gold’: when hyperammonaemia is not from hepatic aetiology
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Case Reports"
DOI: 10.1136/bcr-2017-219441
Abstract: Hyperammonaemia is often caused by decompensated liver disease. However, non-hepatic causes can sometimes result in hyperammonaemia, severe enough to cause symptoms. We report a case of a 65-year-old man with a history of hypertension and… read more here.
Keywords: gold hyperammonaemia; glitters gold; hyperammonaemia hepatic; hyperammonaemia ... See more keywords
Recommendations for the Diagnosis and Therapeutic Management of Hyperammonaemia in Paediatric and Adult Patients
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DOI: 10.3390/nu14132755
Abstract: Hyperammonaemia is a metabolic derangement that may cause severe neurological damage and even death due to cerebral oedema, further complicating the prognosis of its triggering disease. In small children it is a rare condition usually… read more here.
Keywords: hyperammonaemia; management hyperammonaemia; hyperammonaemia paediatric; recommendations diagnosis ... See more keywords