Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pacemaker
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DOI: 10.1111/liv.15476
Abstract: Patients with cirrhosis exhibit features of circadian disruption. Hyperammonaemia has been suggested to impair both homeostatic and circadian sleep regulation. Here, we tested if hyperammonaemia directly disrupts circadian rhythm generation in the central pacemaker, the… read more here.
Keywords: hyperammonaemia; glutamate; hyperammonaemia disrupts; disrupts daily ... See more keywords