LKB1 suppresses androgen synthesis in a mouse model of hyperandrogenism via IGF‐1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12723
Abstract: Polycystic ovary syndrome (PCOS) is a major cause of anovulatory sterility in women, and most PCOS patients exhibit hyperandrogenism (HA). Liver kinase b1 (LKB1) is a tumor suppressor that has recently been reported to be… read more here.
Keywords: via igf; igf signaling; androgen synthesis; hyperandrogenism ... See more keywords
Undernutrition and hyperandrogenism during pregnancy: Role in programming of cardiovascular disease and infertility
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DOI: 10.1002/mrd.23239
Abstract: Maternal nutritional status programs the development of several systems in female offspring, with effects that depend on the severity, duration, and window of development when the nutritional perturbation is imposed. On the basis of the… read more here.
Keywords: pregnancy; hyperandrogenism; disease; undernutrition ... See more keywords
Adipose Tissue is a Potential Source of Hyperandrogenism in Obese Female Rats
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DOI: 10.1002/oby.22198
Abstract: Obesity in females is often associated with metabolic complications and hyperandrogenism, but the sources of androgens are not completely understood. Therefore, this study investigated whether adipose tissue could be a source of androgens promoting hyperandrogenism… read more here.
Keywords: obese female; tissue potential; source; hyperandrogenism ... See more keywords
Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism
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DOI: 10.1016/j.ebiom.2017.01.011
Abstract: Background Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose… read more here.
Keywords: showed increased; hyperandrogenism; igf2 expression; born mothers ... See more keywords
Postmenopausal Hyperandrogenism: Evaluation and Treatment Strategies.
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DOI: 10.1016/j.ecl.2020.12.002
Abstract: Evidence of clinical and/or biochemical androgen excess poses a unique differential in postmenopausal women. Some signs and symptoms of postmenopausal hyperandrogenism can be normal and attributed to the natural aging process. However, the causes of… read more here.
Keywords: androgen excess; hyperandrogenism; hyperandrogenism evaluation; evaluation treatment ... See more keywords
Hyperandrogenic athletes: performance differences in elite-standard 200m and 800m finals
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DOI: 10.1080/02640414.2018.1464620
Abstract: ABSTRACT The purpose of this study was to examine whether the difference in elite-standard track and field performance between women athletes with and without hyperandrogenism reaches the 10–12% difference in performance between men and women,… read more here.
Keywords: difference; hyperandrogenism; 200m 800m; elite standard ... See more keywords
Very low dose of flutamide in the treatment of hyperandrogenism
Sign Up to like & getrecommendations! Published in 2018 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2017.1397114
Abstract: Abstract Hyperandrogenism is a condition affecting 5–10% of adolescents. The aim of this study was to evaluate the efficacy of very low dose of flutamide in the treatment of hyperandrogenism in adolescence. One hundred and… read more here.
Keywords: low dose; hyperandrogenism; treatment; treatment hyperandrogenism ... See more keywords
CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2020.1770724
Abstract: Abstract Objective Polycystic ovarian syndrome is a complex reproductive as well as endocrinological disorder characterized by anovulatory dysfunction, androgen excess and polycystic ovarian morphology. Hyperandrogenism is regarded as a cardinal feature of the disease. It… read more here.
Keywords: hyperandrogenism kashmiri; polycystic ovarian; hyperandrogenism; cyp17 gene ... See more keywords
De Novo and Depot-Specific Androgen Production in Human Adipose Tissue: A Source of Hyperandrogenism in Women with Obesity
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DOI: 10.1159/000521571
Abstract: Introduction: Obesity in women is often associated with hyperandrogenism, but the role of adipose tissue (AT) in androgen synthesis remains unclear. Therefore, we studied whether AT could be a source of androgens promoting hyperandrogenism. Methods:… read more here.
Keywords: androgen production; hyperandrogenism women; adipose tissue; depot specific ... See more keywords
History of Polycystic Ovary Syndrome, Premature Adrenarche, and Hyperandrogenism in Pediatric Endocrinology
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DOI: 10.1159/000526722
Abstract: Descriptions of probable PCOS can be found in ancient Roman writings and in Renaissance art. Attention to domesticated animal reproduction led ancient observers to understand the role of the testes in male phenotypes, proven experimentally… read more here.
Keywords: history polycystic; premature; endocrinology; adrenarche ... See more keywords
SAT-291 Gonadotropin Releasing Hormone Agonist Therapy Improves Hyperandrogenism in an Adolescent with Type A Insulin Resistance Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-291
Abstract: Abstract Background: Type A insulin resistance (IR) is a form of severe IR due to heterozygous mutations in the insulin receptor gene. It presents with acanthosis nigricans, IR, and hyperandrogenism in the absence of obesity… read more here.
Keywords: therapy; treatment; insulin; hyperandrogenism ... See more keywords