Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.619
Abstract: Elevations in serum bilirubin during drug treatment may indicate global liver dysfunction and a high risk of liver failure. However, drugs also can increase serum bilirubin in the absence of hepatic injury by inhibiting specific… read more here.
Keywords: inhibition; hyperbilirubinemia; drug; pharmacology ... See more keywords
In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3665-x
Abstract: PurposeHyperbilirubinemia has been observed in patients treated with tyrosine kinase inhibitor (TKI) drugs. Therefore, it would be beneficial to understand whether there is a relationship between inhibition of uridine-5′-diphosphate glucuronosyltransferase (UGT) 1A1 activity and observed… read more here.
Keywords: tki drugs; inhibition; hyperbilirubinemia; vitro ugt1a1 ... See more keywords
Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity ‐ The hyperbilirubinemia use case
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.01.002
Abstract: &NA; Hyperbilirubinemia is a pathological condition of excessive accumulation of conjugated or unconjugated bilirubin in blood. It has been associated with neurotoxicity and non‐neural organ dysfunctions, while it can also be a warning of liver… read more here.
Keywords: anion transporting; 1b1 1b3; hyperbilirubinemia; oatp1b1 oatp1b3 ... See more keywords
Hyperbilirubinemia and Asphyxia in Children With Dyskinetic Cerebral Palsy.
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2021.02.002
Abstract: BACKGROUND We aimed to study the clinical, etiologic, and radiological characteristics in children with dyskinetic cerebral palsy (DCP) and to compare the etiologic subtypes of hyperbilirubinemia and perinatal asphyxia. METHODS This is a cross-sectional, observational… read more here.
Keywords: hyperbilirubinemia; palsy; dyskinetic cerebral; delay ... See more keywords
Clinical predictive score of predischarge screening for severe hyperbilirubinemia in late preterm and term infants.
Sign Up to like & getrecommendations! Published in 2020 at "Pediatrics and neonatology"
DOI: 10.1016/j.pedneo.2020.02.003
Abstract: BACKGROUND Early identification and appropriate follow-up of infants at risk of severe hyperbilirubinemia are part of preventing complications. This study aims to develop the clinical predictive score to predict subsequent severe hyperbilirubinemia in healthy Thai… read more here.
Keywords: preterm term; risk; severe hyperbilirubinemia; subsequent severe ... See more keywords
Effect of genetic variants of bilirubin metabolism on the degree of hyperbilirubinemia in African-American newborns
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Perinatology"
DOI: 10.1038/jp.2016.232
Abstract: Objective:The objective of our study was to measure the effect of genetic variants of these two enzymes, UGT1A1 and SLCO1B1, in the bilirubin metabolic pathway on the degree of hyperbilirubinemia in a cohort of African-American… read more here.
Keywords: degree hyperbilirubinemia; genetic variants; hyperbilirubinemia; effect genetic ... See more keywords
Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Perinatology"
DOI: 10.1038/jp.2017.167
Abstract: Objective:We investigate whether double phototherapy reduces total serum bilirubin concentration faster than single light during intensive phototherapy with high levels of irradiance using light-emitting diodes.Study Design:Eighty-three infants with gestational age ⩾33 weeks and uncomplicated hyperbilirubinemia… read more here.
Keywords: versus single; double versus; hyperbilirubinemia; single intensive ... See more keywords
Heme oxygenase-1 genetic variants and the conundrum of hyperbilirubinemia in African-American newborns
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Perinatology"
DOI: 10.1038/s41372-017-0039-x
Abstract: BackgroundAfrican-American (AA) infants are known to have, overall, lower bilirubin levels than infants of other ethnicities during their birth hospitalization. However, they are known to have a higher incidence of severe hyperbilirubinemia and are over… read more here.
Keywords: one allele; hyperbilirubinemia; bilirubin; cohbc ... See more keywords
The relationship between hyperbilirubinemia and the promoter region and first exon of UGT1A1 gene polymorphisms in Vietnamese newborns
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Research"
DOI: 10.1038/s41390-020-0825-6
Abstract: Background To investigate the relationship between unexplained indirect hyperbilirubinemia of Vietnamese newborns and the polymorphism of the promoter TATA box and exon 1 of bilirubin uridine diphosphate glucuronosyltransferase (UGT1A1) gene. Methods A total of 149… read more here.
Keywords: vietnamese newborns; hyperbilirubinemia; gene; relationship ... See more keywords
Outcome Analysis of Severe Hyperbilirubinemia in Neonates Undergoing Exchange Transfusion.
Sign Up to like & getrecommendations! Published in 2022 at "Neuropediatrics"
DOI: 10.1055/s-0041-1742156
Abstract: OBJECTIVE Severe neonatal hyperbilirubinemia can cause neurological disability or mortality if not effectively managed. Exchange transfusion (ET) is an efficient treatment to prevent bilirubin neurotoxicity. The purpose of this study was to evaluate outcomes in… read more here.
Keywords: severe hyperbilirubinemia; poor outcomes; analysis; exchange transfusion ... See more keywords
Accuracy of Bilistick (a Point-of-Care Device) to Detect Neonatal Hyperbilirubinemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of tropical pediatrics"
DOI: 10.1093/tropej/fmaa026
Abstract: INTRODUCTION Early diagnosis and appropriate management of neonatal jaundice is crucial in avoiding severe hyperbilirubinemia and brain injury. A low-cost, minimally invasive, point-of-care (PoC) tool for total bilirubin (TB) estimation which can be useful across… read more here.
Keywords: estimation; accuracy bilistick; point care; hyperbilirubinemia ... See more keywords