A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1248
Abstract: Severe hypercholesterolemia (HC, LDL‐C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygenic risk score (PRS) for LDL‐C. read more here.
Keywords: patients severe; hypercholesterolemia; polygenic biomarker; biomarker identify ... See more keywords
[Lipoprotein apheresis : State of the art and case report of the longest HELP treatment worldwide].
Sign Up to like & getrecommendations! Published in 2022 at "Herz"
DOI: 10.1007/s00059-022-05115-9
Abstract: Lipoprotein apheresis is an extracorporeal procedure for the treatment of patients with homozygous familial hypercholesterolemia, patients with severe treatment-resistant hypercholesterolemia and patients with lipoprotein(a) hypercholesterolemia, who show progressive atherosclerotic cardiovascular disease despite optimal treatment. This… read more here.
Keywords: apheresis; hypercholesterolemia; treatment; case ... See more keywords
Diet-induced hypercholesterolemia alters liver glycosaminoglycans and associated-lipoprotein receptors in rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-017-0583-z
Abstract: Glycosaminoglycans (GAGs) play an important role in lipoprotein metabolism. In liver, it facilitates the uptake of remnants through receptor-independent endocytosis. However, changes in liver GAGs during diet-induced hypercholesterolemia with normal levels of fat feeding are… read more here.
Keywords: hypercholesterolemic rats; induced hypercholesterolemia; hypercholesterolemia; diet induced ... See more keywords
Efficacy and Safety of Lomitapide in Hypercholesterolemia
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DOI: 10.1007/s40256-017-0214-7
Abstract: BackgroundDespite extensive use of statins, patients with hypercholesterolemia, especially homozygous familial hypercholesterolemia (HoFH), do not achieve recommended targets of low-density lipoprotein cholesterol (LDL-C). There is an urgent need for novel options that could reduce proatherogenic… read more here.
Keywords: hofh; hypercholesterolemia; efficacy safety; cholesterol ... See more keywords
Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia
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DOI: 10.1007/s40256-020-00421-1
Abstract: Rosuvastatin/ezetimibe combines two lipid-lowering agents: rosuvastatin, an HMG-CoA reductase inhibitor (i.e. statin) with particularly strong inhibitory effects on hepatic cholesterol synthesis, and ezetimibe, which inhibits the intestinal absorption of cholesterol. A fixed-dose combination (FDC) of… read more here.
Keywords: rosuvastatin ezetimibe; rosuvastatin; hypercholesterolemia; cholesterol ... See more keywords
Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.05.015
Abstract: Background and aims Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical… read more here.
Keywords: polygenic hypercholesterolemia; hypercholesterolemia; preclinical atherosclerosis; atherosclerosis treated ... See more keywords
Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.06.916
Abstract: BACKGROUND AND AIMS Oxidative modification of lipoproteins is a crucial step in atherosclerosis development. Isotopic-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to reactive oxygen species-initiated chain reaction of lipid peroxidation than regular hydrogenated (H-)PUFAs.… read more here.
Keywords: hypercholesterolemia; reinforced polyunsaturated; cholesterol; lipid peroxidation ... See more keywords
NUtraceutical TReatment for hYpercholesterolemia in HIV-infected patients: The NU-TRY(HIV) randomized cross-over trial.
Sign Up to like & getrecommendations! Published in 2019 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.11.026
Abstract: BACKGROUND AND AIMS Despite hypercholesterolemia has been recognized to increase cardiovascular risk in human immunodeficiency virus (HIV)-infected patients, cholesterol-lowering therapy is underused in this population, due to fear of drug-drug interactions with antiretroviral therapy (ART).… read more here.
Keywords: hypercholesterolemia; treatment; cholesterol; infected patients ... See more keywords
Predicted pathogenic mutations in STAP1 are not associated with clinically defined familial hypercholesterolemia.
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DOI: 10.1016/j.atherosclerosis.2019.11.025
Abstract: BACKGROUND AND AIMS Autosomal dominant familial hypercholesterolemia (FH) is caused by mutations in LDLR,APOB and PCSK9. Two new putative loci causing FH have been identified recently, the p.(Leu167del) mutation in APOE and new mutations in… read more here.
Keywords: hypercholesterolemia; stap1; family; predicted pathogenic ... See more keywords
Shortcomings on genetic testing of Familial hypercholesterolemia (FH) in India: Can we collaborate to establish Indian FH registry?
Sign Up to like & getrecommendations! Published in 2021 at "Indian Heart Journal"
DOI: 10.1016/j.ihj.2021.11.185
Abstract: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder that affects ∼1 in 250–500 individuals globally. The only prevalence study in India shows FH in 15% of patients with premature CAD in North Indians. There… read more here.
Keywords: hypercholesterolemia; genetic testing; shortcomings genetic; india ... See more keywords
Reverse Cascade Screening for Familial Hypercholesterolemia
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DOI: 10.1016/j.pedn.2018.09.011
Abstract: Problem Cardiovascular disease (CVD) is the leading cause of death in the U.S. and in most Western countries. Early identification and treatment of individuals with elevated levels of atherogenic cholesterol, a major contributor to CVD,… read more here.
Keywords: hypercholesterolemia; cholesterol screening; reverse cascade; familial hypercholesterolemia ... See more keywords