Hypercholesterolemia induced by spontaneous oligogenic mutations in rhesus macaques (Macaca mulatta).
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medical primatology"
DOI: 10.1111/jmp.12642
Abstract: BACKGROUND A rhesus macaque with the fourth highest plasma cholesterol (CH) levels of 501 breeding macaques was identified 22 years ago. Seven offspring with gene mutations causing hypercholesterolemia were obtained. METHODS Activity of low-density lipoprotein receptor… read more here.
Keywords: spontaneous oligogenic; hypercholesterolemia induced; oligogenic mutations; induced spontaneous ... See more keywords
Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed: The Impact of Diet and Statin Treatment in a Preclinical Animal Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158596
Abstract: High-density lipoproteins (HDL) undergo adverse remodeling and loss of function in the presence of comorbidities. We assessed the potential of lipid-lowering approaches (diet and rosuvastatin) to rescue hypercholesterolemia-induced HDL dysfunction. Hypercholesterolemia was induced in 32… read more here.
Keywords: apolipoprotein content; hypercholesterolemia induced; induced hdl; hypercholesterolemia ... See more keywords