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   Articles with "hyperexcitability" as a keyword



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Cortical hyperexcitability evolves with disease progression in ALS

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recommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51039

Abstract: Cortical hyperexcitability has been established as an early feature of amyotrophic lateral sclerosis (ALS). The evolution of cortical hyperexcitability with ALS progression remains to be fully elucidated. This study aims to investigate changes in cortical… read more here.

Keywords: hyperexcitability; cortical hyperexcitability; hyperexcitability evolves; disease progression ... See more keywords
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FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.03.037

Abstract: Mutations in the nuclear localization signal of the RNA binding protein FUS cause both Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). These mutations result in a loss of FUS from the nucleus and the… read more here.

Keywords: drosophila; hyperexcitability; caz; fus ... See more keywords
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Stimulus-Driven Cortical Hyperexcitability in Individuals with Charles Bonnet Hallucinations

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recommendations! Published in 2018 at "Current Biology"

DOI: 10.1016/j.cub.2018.08.058

Abstract: Throughout the lifespan, the cerebral cortex adapts its structure and function in response to changing sensory input [1, 2]. Whilst such changes are typically adaptive, they can be maladaptive when they follow damage to the… read more here.

Keywords: hyperexcitability; cortical hyperexcitability; field; peripheral visual ... See more keywords
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Minocycline prevents neuronal hyperexcitability and neuroinflammation in medial prefrontal cortex, as well as memory impairment caused by repeated toluene inhalation in adolescent rats.

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recommendations! Published in 2020 at "Toxicology and applied pharmacology"

DOI: 10.1016/j.taap.2020.114980

Abstract: Toluene can be intentionally misused by adolescents to experience psychoactive effects. Toluene has a complex mechanism of action and broad behavioral effects, among which memory impairment is reported consistently. We have previously reported that repeated… read more here.

Keywords: hyperexcitability; toluene inhalation; memory impairment; repeated toluene ... See more keywords
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Hyperexcitability and impaired intracortical inhibition in patients with fragile-X syndrome

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recommendations! Published in 2019 at "Translational Psychiatry"

DOI: 10.1038/s41398-019-0650-z

Abstract: Fragile-X syndrome (FXS) is characterized by neurological and psychiatric problems symptomatic of cortical hyperexcitability. Recent animal studies identified deficient γ-aminobutyricacid (GABA) inhibition as a key mechanism for hyperexcitability in FXS, but the GABA system remains… read more here.

Keywords: hyperexcitability; intracortical facilitation; fragile syndrome; inhibition ... See more keywords
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In vivo KPT-350 treatment decreases cortical hyperexcitability following traumatic brain injury

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recommendations! Published in 2020 at "Brain Injury"

DOI: 10.1080/02699052.2020.1807056

Abstract: ABSTRACT Primary Objective We tested whether KPT-350, a novel selective inhibitor of nuclear export, could attenuate cortical network hyperexcitability, a major risk factor for developing post-traumatic epilepsy (PTE) following traumatic brain injury (TBI). Research Design… read more here.

Keywords: hyperexcitability; brain; kpt 350; following traumatic ... See more keywords
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Central neuropathic pain in multiple sclerosis is associated with impaired innocuous thermal pathways and neuronal hyperexcitability.

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recommendations! Published in 2021 at "Pain medicine"

DOI: 10.1093/pm/pnab103

Abstract: OBJECTIVE About a third of patients with multiple sclerosis (MS) suffer from chronic and excruciating central neuropathic pain (CNP). The mechanism underlying CNP in MS is not clear, since previous studies are scarce and their… read more here.

Keywords: cnp; central neuropathic; hyperexcitability; multiple sclerosis ... See more keywords
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An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.

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recommendations! Published in 2022 at "Pain"

DOI: 10.1097/j.pain.0000000000002656

Abstract: ABSTRACT Altered bone morphogenetic protein (BMP) signaling is associated with many musculoskeletal diseases. However, it remains unknown whether BMP dysfunction has direct contribution to debilitating pain reported in many of these disorders. Here we identified… read more here.

Keywords: pain; activating mutation; neuropathic pain; hyperexcitability ... See more keywords
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Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression

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recommendations! Published in 2020 at "NeuroReport"

DOI: 10.1097/wnr.0000000000001520

Abstract: Cervical nerve root injury induces a host of inflammatory mediators in the spinal cord that initiate and maintain neuronal hyperexcitability and pain. Secretory phospholipase A2 (sPLA2) is an enzyme that has been implicated as a… read more here.

Keywords: secretory phospholipase; spla2; neuronal hyperexcitability; nerve root ... See more keywords
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Mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

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recommendations! Published in 2020 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.15214

Abstract: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically characterised by mislocalisation of the RNA‐binding protein TAR‐DNA‐binding protein 43 (TDP‐43) from the nucleus to the cytoplasm. Changes to neuronal excitability and synapse dysfunction in… read more here.

Keywords: tdp; motor cortex; mislocalisation; hyperexcitability ... See more keywords
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Seizing the Alzheimer’s Brain: A Role for Sirtuin 3 in Hyperexcitability

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recommendations! Published in 2020 at "Epilepsy Currents"

DOI: 10.1177/1535759720932157

Abstract: SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer’s Disease Model 1 Cheng A, Wang J, Ghena N, Zhao Q, Perone I, King TM, Veech RL, Gorospe M, Wan R,… read more here.

Keywords: hyperexcitability; appps1 mice; sirt3; neuronal network ... See more keywords