Appropriateness of action prompts for hypoglycaemia and hyperglycaemia in type 2 diabetes selfâmanagement apps
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3235
Abstract: Control of blood glucose levels is needed not only to alleviate symptoms of hypoglycaemia and hyperglycaemia, but also to prevent or delay diabetesârelated complications. Advice for glucose control is usually provided to patients by members… read more here.
Keywords: action prompts; hypoglycaemia hyperglycaemia; hyperglycaemia; appropriateness action ... See more keywords
Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4390-4
Abstract: Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation abnormalities and later by clinical heart failure in the absence of dyslipidaemia, hypertension and coronary artery disease. Insulin resistance, hyperinsulinaemia and hyperglycaemia are each… read more here.
Keywords: heart; diabetic cardiomyopathy; hyperglycaemia; insulin resistance ... See more keywords
The association of hyperglycaemia and insulin resistance with incident depressive symptoms over 4 years of follow-up: The Maastricht Study
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05247-9
Abstract: Depression is twice as common in individuals with type 2 diabetes as in the general population. However, it remains unclear whether hyperglycaemia and insulin resistance are directly involved in the aetiology of depression. Therefore, we… read more here.
Keywords: depressive symptoms; insulin; hyperglycaemia; insulin resistance ... See more keywords
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118667
Abstract: AIM Diabetes is a high-risk factor for neurocognitive dysfunction. Diabetic acute hyperglycaemia accompanied by high osmotic pressure can induce immune cell dysfunction, but its mechanism of action in brain microglia remains unclear. This study aimed… read more here.
Keywords: piezo1; hyperglycaemia; acute hyperglycaemia; jnk1 mtor ... See more keywords
The impact of hyperglycaemia on PKM2-mediated NLRP3 inflammasome/stress granule signalling in macrophages and its correlation with plaque vulnerability: an in vivo and in vitro study.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154231
Abstract: BACKGROUND The mechanism of pyruvate kinase M2 (PKM2)-mediated inflammatory signalling in macrophages when plaques rupture and the impact of hyperglycaemia on the signalling are unclear. The present study aimed to explore the impact of hyperglycaemia… read more here.
Keywords: nlrp3 inflammasome; hyperglycaemia; stress granule; pkm2 mediated ... See more keywords
Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice
Sign Up to like & getrecommendations! Published in 2018 at "Vascular Pharmacology"
DOI: 10.1016/j.vph.2018.01.002
Abstract: Vascular dysfunction in small resistance arteries is observed during chronic elevations in blood glucose. Hyperglycaemia-associated effects on endothelium-dependent vasodilation have been well characterized, but effects on conducted vasodilation in the resistance vasculature are not known.… read more here.
Keywords: vasculature; conducted vasodilation; vasodilation resistance; vasodilation ... See more keywords
Meal-specific food patterns and the incidence of hyperglycemia in a Chinese adult population
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Nutrition"
DOI: 10.1017/s000711451700174x
Abstract: Abstract This study aimed to examine the association between meal-specific food patterns and incident hyperglycaemia in a Chinese adult population. Adults aged 20 years and older (n 1056) were followed from 2002 to 2007. Dietary… read more here.
Keywords: food patterns; incident hyperglycaemia; hyperglycaemia; meal specific ... See more keywords
The relationship between proportions of carbohydrate and fat intake and hyperglycaemia risk in Chinese adults
Sign Up to like & getrecommendations! Published in 2024 at "Public Health Nutrition"
DOI: 10.1017/s1368980024001204
Abstract: Abstract Objective: To address the relationship between the proportions of carbohydrates and fat and hyperglycaemia in the Chinese population. Design: A cross-section research involving data from the China Health and Nutrition Survey in 2009, and… read more here.
Keywords: carbohydrate; carbohydrate low; fat diet; low fat ... See more keywords
Neuropsychiatric disorders: Side effects of olanzapine worsened by metabolic dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.183
Abstract: generation antipsychotic drug, can cause metabolic side effects, including hyperphagia, weight gain and acute hyperglycaemia. Previously, researchers used lean, healthy rodents to investigate the mechanisms behind olanzapine-associated acute hyperglycaemia; however, individuals with schizophrenia are often… read more here.
Keywords: insulin; metabolic side; hyperglycaemia; mice ... See more keywords
Hyperglycaemia up-regulates placental growth factor (PlGF) expression and secretion in endothelial cells via suppression of PI3 kinase-Akt signalling and activation of FOXO1
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95511-8
Abstract: Placenta growth factor (PlGF) is a pro-inflammatory angiogenic mediator that promotes many pathologies including diabetic complications and atherosclerosis. Widespread endothelial dysfunction precedes the onset of these conditions. As very little is known of the mechanism(s)… read more here.
Keywords: akt; secretion; plgf expression; foxo1 ... See more keywords
Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2022.2105365
Abstract: CONTEXT Persistent hyperglycaemia increases SET7/9 expression and endoplasmic reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular epithelial cells leading to diabetic kidney disease (DKD). OBJECTIVE Current study explores the renoprotective potential… read more here.
Keywords: inflammation; hyperglycaemia induced; renal tubular; hyperglycaemia ... See more keywords