Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2022.2105365
Abstract: CONTEXT Persistent hyperglycaemia increases SET7/9 expression and endoplasmic reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular epithelial cells leading to diabetic kidney disease (DKD). OBJECTIVE Current study explores the renoprotective potential… read more here.
Keywords: inflammation; hyperglycaemia induced; renal tubular; hyperglycaemia ... See more keywords
Hyperglycaemia‐induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS‐mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein
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DOI: 10.1111/dme.14713
Abstract: Diabetic population have a twofold to threefold increased risk of developing liver cancer, and hyperglycaemia is a prime causative factor that propends the tumour cells to undergo aggressive metabolic growth. In this study, we aimed… read more here.
Keywords: cell proliferation; induced human; hyperglycaemia induced; hepg2 cell ... See more keywords
IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells
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DOI: 10.18632/oncotarget.27650
Abstract: Localized prostate cancer (PCa) is a manageable disease but for most men with metastatic disease, it is often fatal. A western diet has been linked with PCa progression and hyperglycaemia has been associated with the… read more here.
Keywords: prostate; mesenchymal transition; hyperglycaemia induced; hyperglycaemia ... See more keywords
Ameliorative Effects of a Rhenium (V) Compound with Uracil-Derived Ligand Markers Associated with Hyperglycaemia-Induced Renal Dysfunction in Diet-Induced Prediabetic Rats
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DOI: 10.3390/ijms232315400
Abstract: Kidney disease is characterised by the improper functioning of the kidney as a result of kidney damage caused by hyperglycaemia-induced oxidative stress. The moderate hyperglycaemia seen in prediabetes can be treated using a combination of… read more here.
Keywords: rhenium compound; hyperglycaemia induced; kidney; effects rhenium ... See more keywords