Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization
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DOI: 10.1002/lt.25470
Abstract: Hyperglycemia aggravates hepatic ischemia/reperfusion injury (IRI), but the underlying mechanism for the aggravation remains elusive. Sphingosine‐1‐phosphate (S1P) and sphingosine‐1‐phosphate receptors (S1PRs) have been implicated in metabolic and inflammatory diseases. Here, we discuss whether and how… read more here.
Keywords: polarization; ischemia reperfusion; hyperglycemia; sphingosine phosphate ... See more keywords
Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.
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DOI: 10.1007/s00109-018-1707-9
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of reactive oxygen… read more here.
Keywords: inducible factor; hif1; sensory neurons; hyperglycemia ... See more keywords
Improvement in Hyperglycemia Prevents Surgical Site Infection Irrespective of Insulin Therapy in Non-diabetic Patients Undergoing Gastrointestinal Surgery
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DOI: 10.1007/s00268-020-05371-y
Abstract: Background Intensive glycemic control is recommended to prevent surgical site infections (SSI). Our aim was to evaluate retrospectively the effect of improvement in hyperglycemia irrespective of insulin use on the incidence of SSI in non-diabetic… read more here.
Keywords: surgery; insulin therapy; diabetic patients; hyperglycemia ... See more keywords
Trajectories of energy intake distribution and subsequent risk of hyperglycemia among Chinese adults: findings from the China Health and Nutrition Survey (1997–2018)
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DOI: 10.1007/s00394-021-02745-3
Abstract: Few studies have examined the secular trend of the energy intake distribution, and its effect on future risk of hyperglycemia. This study aims to describe trajectories of energy intake distribution over 12 years and relate… read more here.
Keywords: risk; energy intake; energy; group ... See more keywords
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways
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DOI: 10.1007/s00395-020-00834-8
Abstract: Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K+ channel remodeling and increased arrhythmia risk. However, the exact signaling mechanism by which diabetic hyperglycemia regulates cardiac K+ channels remains elusive. Here, we show that… read more here.
Keywords: nox2 ros; hyperglycemia regulates; camkii; hyperglycemia ... See more keywords
Endothelium-dependent vasodilation in the cerebral arterioles of rats deteriorates during acute hyperglycemia and then is restored by reducing the glucose level
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DOI: 10.1007/s00540-018-2507-7
Abstract: PurposeAcute hyperglycemia in patients with traumatic brain injury correlates with a poor neurological outcome. We investigated the endothelium function of rat cerebral arterioles during acute hyperglycemia and after reducing the glucose levels using insulin. We… read more here.
Keywords: endothelium; reducing glucose; cerebral arterioles; hyperglycemia ... See more keywords
Intraoperative hyperglycemia in patients with an elevated preoperative C-reactive protein level may increase the risk of acute kidney injury after cardiac surgery
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DOI: 10.1007/s00540-020-02849-w
Abstract: The effect of hyperglycemia on acute kidney injury (AKI) in patients undergoing cardiac surgery is unclear and may involve as yet unexplored factors. We hypothesized differential effects of intraoperative hyperglycemia on AKI after cardiac surgery… read more here.
Keywords: intraoperative hyperglycemia; level; cardiac surgery; hyperglycemia ... See more keywords
Stress Hyperglycemia Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis
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DOI: 10.1007/s10620-021-06982-8
Abstract: Stress hyperglycemia is common in critical illness but it has not been clearly studied in patients with acute pancreatitis (AP). This study aimed to investigate the specific blood glucose (BG) level that defines stress hyperglycemia… read more here.
Keywords: acute pancreatitis; clinical outcomes; stress hyperglycemia; persistent organ ... See more keywords
Factors Associated with Risk of Perinatal Depressive Symptoms Among Puerto Rican Women with Hyperglycemia
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DOI: 10.1007/s10995-022-03429-y
Abstract: Rates of perinatal depression and pregnancy hyperglycemia are higher in Hispanic women as compared to non-Hispanic white women. In turn, depressive symptoms may reduce a woman’s ability to engage in lifestyle changes that could reduce… read more here.
Keywords: hyperglycemia; depressive symptoms; risk; factors associated ... See more keywords
Interleukin-13 ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke
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DOI: 10.1007/s11011-020-00596-1
Abstract: Hyperglycemia is a well-known indicator of stroke prognosis, and one-third of nondiabetic patients develop postischemic hyperglycemia during the acute phase of stroke; this is related to relatively poor prognosis, high mortality, and impaired neurological recovery.… read more here.
Keywords: hepatic gluconeogenesis; rat model; postischemic hyperglycemia; hyperglycemia ... See more keywords
Management of Hyperglycemia and Diabetes in the Emergency Department
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DOI: 10.1007/s11892-017-0883-2
Abstract: Purpose of ReviewHyperglycemia in the emergency department (ED) is being recognized as a public health problem and presents a clinical challenge. This review critically summarizes available evidence on the burden, etiology, diagnosis, and practical management… read more here.
Keywords: management; emergency department; hyperglycemia; management hyperglycemia ... See more keywords