Teneligliptin enhances the beneficial effects of GLP-1 in endothelial cells exposed to hyperglycemic conditions
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DOI: 10.18632/oncotarget.22849
Abstract: High-glucose-induced oxidative stress contributes to cardiovascular endothelial damage in diabetes. Glucagon-like peptide 1 (GLP-1) is beneficial to endothelial cells, but its effects are diminished when cells are continuously exposed to high glucose. Teneligliptin is a… read more here.
Keywords: teneligliptin; hyperglycemic conditions; beneficial effects; stress ... See more keywords
Impairment of Autophagy Causes Superoxide Formation and Caspase Activation in 661 W Cells, a Cell Line for Cone Photoreceptors, under Hyperglycemic Conditions
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DOI: 10.3390/ijms21124240
Abstract: Microvascular changes are the earliest adverse events in diabetic retinopathy, but recent studies have shown that oxidative stress induced by photoreceptors is associated with the development of the retinopathy. The purpose of this study was… read more here.
Keywords: caspase; cell line; hyperglycemic conditions; 661 cells ... See more keywords
Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions
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DOI: 10.3390/ijms21197207
Abstract: In diabetes mellitus, hyperglycemia promotes the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) to enhance medial vascular calcification, a common complication strongly associated with cardiovascular disease and mortality. The mechanisms involved are, however, still… read more here.
Keywords: sgk1; osteogenic transdifferentiation; calcification; high glucose ... See more keywords
Mesenchymal Stem Cells Potentiate the Vasculogenic Capacity of Endothelial Colony-Forming Cells under Hyperglycemic Conditions
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DOI: 10.3390/life12040469
Abstract: Many studies have demonstrated a reduced number and vasculogenic capacity of endothelial colony-forming cells (ECFCs) in diabetic patients. However, whether the vasculogenic capacity of ECFCs is recovered or not when combined with pericyte precursors, mesenchymal… read more here.
Keywords: ecfcs mscs; capacity endothelial; vasculogenic capacity; hyperglycemic conditions ... See more keywords