Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins
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DOI: 10.1155/2017/6785852
Abstract: We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet.… read more here.
Keywords: hyperglycemic stress; nrf2 dependent; inhibitor; aldose reductase ... See more keywords