Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.2749
Abstract: Importance Given that mycosis fungoides-cutaneous T-cell lymphoma (MF/CTCL) is chronic, there is a need for additional therapies with minimal short- and long-term adverse effects. Topical synthetic hypericin ointment, 0.25%, activated with visible light is a… read more here.
Keywords: cycle; early stage; hypericin; trial ... See more keywords
On the origin of photodynamic activity of hypericin and its iodine‐containing derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.27002
Abstract: The main photophysical properties, useful for establishing whether hypericin in anionic form and some of its derivatives containing heavy atoms such as iodine, can be proposed for their use in photodynamic therapy, were determined using… read more here.
Keywords: origin photodynamic; hypericin; hypericin iodine; photodynamic activity ... See more keywords
Spectroscopic and photostability study of water-soluble hypericin encapsulated with polyvinylpyrrolidone.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2020.106454
Abstract: Hypericin has gained great attention as a powerful photosensitizing and fluorescent agent for photodynamic therapy (PDT) and fluorescence diagnosis (FD) of cancer. However, native hypericin is hydrophobic and nearly insoluble in aqueous media which hinders… read more here.
Keywords: photostability; hypericin pvp; water soluble; hypericin ... See more keywords
Hypericin inclusion complexes encapsulated in liposomes for antimicrobial photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118666
Abstract: The naturally occurring anthraquinone derivative hypericin is a highly potent photosensitiser. Several in vitro studies show high phototoxicity of the pigment towards gram-positive bacteria. Nevertheless, the highly lipophilic nature and poor bioavailability prevent its application… read more here.
Keywords: antimicrobial photodynamic; inclusion; photodynamic therapy; hypericin ... See more keywords
Preparation and validation of cyclodextrin-based excipients for radioiodinated hypericin applied in a targeted cancer radiotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120393
Abstract: BACKGROUND Iodine-131 labeled hypericin (131I-Hyp) has been utilized as a necrosis-avid theragnostic tracer in a dual targeting pan-anticancer strategy called OncoCiDia. Widespread use of previously-tested solvent dimethyl sulfoxide (DMSO) is limited by safety concerns. To… read more here.
Keywords: microscopy; cyclodextrin; histopathology; 131i hyp ... See more keywords
Methodological aspects of biologically active compounds quantification in the genus Hypericum
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.03.048
Abstract: HIGHLIGHTSTwo Hypericum species, two vegetative organs and two solvents were compared.Metabolites accumulated mainly in leaves (rutin, hyperoside, quercetin and hypericin).Chlorogenic acid and quercitrin were not detected in stem of both species.EtOH was suitable for extraction… read more here.
Keywords: extraction; methodological aspects; hypericin; aspects biologically ... See more keywords
Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels.
Sign Up to like & getrecommendations! Published in 2019 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2019.08.016
Abstract: Hypericin (Hyp) is a naturally occurring compound used as photosensitizer in photodynamic therapy and diagnosis. Recently, we have shown that Hyp presence alone, without illumination, resulted in substantial biological effects at several sub-cellular levels. Hyp… read more here.
Keywords: hyp; bh3; hypericin; bcl2 ... See more keywords
Searching for combination therapy by clustering methods: Stimulation of PKC in Golgi apparatus combined with hypericin induced PDT.
Sign Up to like & getrecommendations! Published in 2020 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2020.101813
Abstract: Cancer cells metabolism is nowadays a very attractive target of anticancer treatments. This work focuses on protein kinase C (PKC) signaling in the U87 MG glioma. By means of western blot, fluorescence and time-resolved fluorescence… read more here.
Keywords: combination therapy; hypericin; golgi apparatus; therapy ... See more keywords
Biodegradable hypericin-containing nanoparticles for necrosis targeting and fluorescence imaging.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b01238
Abstract: Necrosis targeting and imaging has significant implications for evaluating tumor growth, therapeutic response, and delivery of therapeutics to peri-necrotic tumor zones. Hypericin is a hydrophobic molecule with high necrosis affinity and fluorescence imaging properties. To… read more here.
Keywords: targeting fluorescence; fluorescence imaging; hypericin; necrosis targeting ... See more keywords
The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.1c22439
Abstract: Hypericin is a photosensitizing drug that is active against membrane-enveloped viruses and therefore constitutes a promising candidate for the treatment of SARS-CoV-2 infections. The antiviral efficacy of hypericin is largely determined by its affinity toward… read more here.
Keywords: sars cov; hypericin; cov reveals; interaction hypericin ... See more keywords
Thermoresponsive Liposomes for Photo-Triggered Release of Hypericin Cyclodextrin Inclusion Complex for Efficient Antimicrobial Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c02741
Abstract: Antimicrobial strategies with high efficacy against bacterial infections are urgently needed. The development of effective therapies to control bacterial infections is still a challenge. Herein, near-infrared (NIR)-activated thermosensitive liposomes (TSL) were loaded with the NIR-dye… read more here.
Keywords: inclusion complex; hyp; hypericin; cyclodextrin inclusion ... See more keywords