Low-dose subcutaneous tocilizumab to prevent disease progression in patients with moderate COVID-19 pneumonia and hyperinflammation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.07.078
Abstract: Abstract Aim The aim of the study was to evaluate the safety and efficacy profile of low-dose tocilizumab (TCZ) administered subcutaneously to patients with moderate COVID-19 pneumonia and hyperinflammation to prevent disease progression. Methods We… read more here.
Keywords: hyperinflammation; low dose; moderate covid; patients moderate ... See more keywords
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation
Sign Up to like & getrecommendations! Published in 2019 at "Nature immunology"
DOI: 10.1038/s41590-019-0539-2
Abstract: Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs)… read more here.
Keywords: oxidized phospholipids; hyperinflammation; phospholipids reprogram; metabolism ... See more keywords
1561: USE OF AN INTERLEUKIN-1 RECEPTOR ANTAGONIST FOR SUSPECTED SEPSIS WITH HYPERINFLAMMATION IN CHILDREN
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000648152.30809.3c
Abstract: Introduction/Hypothesis: A subset of patients with severe sepsis is recognized to have pathologic immune system activation. Specific inflammation phenotypes are associated with greater mortality. Recent studies have shown improved outcomes of patients with hyperferritinemic sepsis… read more here.
Keywords: hyperinflammation; sepsis; suspected sepsis; receptor antagonist ... See more keywords
Neutrophil developmental defects cause hyperinflammation in cherubism
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5723270
Abstract: Cherubism is a rare autosomal dominant disease caused mainly by a P416R point mutation of Src homology 3 Domain Binding Protein 2 (SH3BP2). Though macrophages and osteoblasts were thought to be the major contributors to… read more here.
Keywords: hyperinflammation; defects cause; neutrophil developmental; physiology ... See more keywords
Hyperinflammation, apoptosis, and organ damage
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221090454
Abstract: The cytokine storm (CS) in hyperinflammation is characterized by high levels of cytokines, extreme activation of innate as well as adaptive immune cells and initiation of apoptosis. High levels of apoptotic cells overwhelm the proper… read more here.
Keywords: hyperinflammation; recognition; damage; hyperinflammation apoptosis ... See more keywords
Hyperinflammation in COVID-19 Obese Patients Treated With Tocilizumab: A Successful Case Series
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Investigative Medicine High Impact Case Reports"
DOI: 10.1177/23247096211037442
Abstract: The cytokine storm syndrome has been suggested as a mechanism in the pathophysiology of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; COVID-19 [coronavirus disease 2019]) infection. Drugs such as tocilizumab, an interleukin-6 antagonist, have shown… read more here.
Keywords: hyperinflammation; covid obese; case series; obese patients ... See more keywords
Neutrophil Metabolic Rewiring in Severe and Mild COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood-2021-153977
Abstract: SARS-CoV-2 infection can cause severe respiratory disease resulting in hospitalization and death in some people, but in others it causes a mild disease or is asymptomatic. The causes of severe COVID-19 are of profound public… read more here.
Keywords: hyperinflammation; covid; mild covid; covid patients ... See more keywords
COVID‐19: lambda interferon against viral load and hyperinflammation
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202012465
Abstract: Coronavirus disease 2019 (COVID‐19), triggered by the betacoronavirus SARS‐CoV‐2, has become one of the worst pandemics of our time that has already caused more than 250,000 deaths (JHU data‐05/06/2020, https://coronavirus.jhu.edu/). Effective therapeutic approaches are urgently… read more here.
Keywords: lambda; hyperinflammation; covid; covid lambda ... See more keywords
Chasing the Ghost: Hyperinflammation Does Not Cause Sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.910516
Abstract: Sepsis is infection sufficient to cause illness in the infected host, and more severe forms of sepsis can result in organ malfunction or death. Severe forms of Coronavirus disease-2019 (COVID-19), or disease following infection with… read more here.
Keywords: sepsis; hyperinflammation; cause; concept ... See more keywords
The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation
Sign Up to like & getrecommendations! Published in 2020 at "Immune Network"
DOI: 10.4110/in.2020.20.e15
Abstract: An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain… read more here.
Keywords: hyperinflammation; butyrate attenuating; butyrate; pathogenic bacterial ... See more keywords