Egr‐1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia‐induced insulin resistance in the liver in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13537
Abstract: During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long‐term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown.… read more here.
Keywords: resistance liver; hyperinsulinemia; liver; type diabetes ... See more keywords
ETNPPL modulates hyperinsulinemia‐induced insulin resistance through the SIK1/ROS‐mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30993
Abstract: Hyperinsulinemia is a critical risk factor for the pathogenesis of insulin resistance (IR) in metabolic tissues, including the liver. Ethanolamine phosphate phospholyase (ETNPPL), a newly discovered metabolic enzyme that converts phosphoethanolamine (PEA) to ammonia, inorganic… read more here.
Keywords: pi3k akt; sik1; inactivation; hyperinsulinemia induced ... See more keywords
Evidence of muscle loss delay and improvement of hyperinsulinemia and insulin resistance in Duchenne muscular dystrophy supplemented with omega-3 fatty acids: A randomized study.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2018.10.017
Abstract: BACKGROUND & AIMS Duchenne Muscular Dystrophy (DMD) is the most prevalent dystrophy of childhood and is characterized by generalized motor delays due to progressive muscular weakness, leading to loss of muscle mass. Additionally, patients with… read more here.
Keywords: hyperinsulinemia; loss; mass; study ... See more keywords
Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.09.001
Abstract: Hyperinsulinemia activates brain Akt and PKC-λ/ι and increases Aβ1-40/42 and phospho-tau in insulin-resistant animals. Here, we examined underlying mechanisms in mice, neuronal cells, and mouse hippocampal slices. Like Aβ1-40/42, β-secretase activity was increased in insulin-resistant… read more here.
Keywords: neuronal cells; hyperinsulinemia; pkc; brain ... See more keywords
Higher scores of dietary and lifestyle inflammatory indices are associated with increased risk of insulin-related disorders in Iranian adults
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Nutrition"
DOI: 10.1038/s41430-022-01143-0
Abstract: The roles of potential inflammation of diet and lifestyle in the risk of insulin-related disorders are unclear. In the current study, we aimed to assess the relationship between dietary inflammation scores (DIS), lifestyle inflammation scores… read more here.
Keywords: insulin related; score; risk; related disorders ... See more keywords
Explainable data mining model for hyperinsulinemia diagnostics
Sign Up to like & getrecommendations! Published in 2024 at "Connection Science"
DOI: 10.1080/09540091.2024.2325496
Abstract: ABSTRACT In our research, we present a data mining model for the early diagnosis of hyperinsulinemia, potentially reducing the risk of diabetes, heart disease, and other chronic conditions. The dataset, gathered from 2019 to 2022… read more here.
Keywords: mining model; data mining; explainable data; model ... See more keywords
Role for insulin sensitivity in the cerebrovascular response to hyperinsulinemia in young adults
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731769
Abstract: Objective: Cerebral blood flow is highly regulated and cerebrovascular responsiveness to vasodilatory stimuli is predictive of brain health. In preclinical animal models, insulin elicits cerebrovascular dilation and subsequent increases in cerebral blood flow. Contrary to… read more here.
Keywords: physiology; insulin sensitivity; blood; hyperinsulinemia ... See more keywords
Abstract B055: Hyperinsulinemia acts via acinar cell insulin receptors to drive obesity-associated pancreatic cancer initiation
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.panca2023-b055
Abstract: The rising incidence of pancreatic cancer is largely driven by increased prevalence of obesity and type 2 diabetes (T2D). Hyperinsulinemia is a cardinal feature of obesity and T2D, and is associated with increased cancer incidence… read more here.
Keywords: cancer; insulin; obesity; pancreatic cancer ... See more keywords
Abstract C043: Hyperinsulinemia promotes pancreatic cancer progression by altering tumor metabolism
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.pancreatic24-c043
Abstract: Metabolic diseases, such as type 2 diabetes (T2D), insulin resistance, and obesity, often accompany pancreatic ductal adenocarcinoma (PDAC), and they are associated with reduced survival. Hyperinsulinemia is a common hallmark symptom shared by those disorders… read more here.
Keywords: cancer; insulin; progression; tumor ... See more keywords
The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.162382
Abstract: Metabolic crosstalk from skeletal muscle to multiple organs is important for maintaining homeostasis, and its dysregulation can lead to various diseases. Chronic glucocorticoid administration often induces muscle atrophy and metabolic disorders such as diabetes and… read more here.
Keywords: crucial role; glucocorticoid; muscle signaling; muscle ... See more keywords
Role of Endothelin-1 Receptors in Limiting Leg Blood Flow and Glucose Uptake during Hyperinsulinemia in Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac008
Abstract: Skeletal muscle insulin resistance is a hallmark of individuals with type 2 diabetes mellitus (T2D). In healthy individuals insulin stimulates vasodilation, which is markedly blunted in T2D; however, the mechanism(s) remain incompletely understood. Investigations in… read more here.
Keywords: leg; eta receptor; type diabetes; glucose uptake ... See more keywords