Egr‐1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia‐induced insulin resistance in the liver in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13537
Abstract: During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long‐term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown.… read more here.
Keywords: resistance liver; hyperinsulinemia; liver; type diabetes ... See more keywords
ETNPPL modulates hyperinsulinemia‐induced insulin resistance through the SIK1/ROS‐mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30993
Abstract: Hyperinsulinemia is a critical risk factor for the pathogenesis of insulin resistance (IR) in metabolic tissues, including the liver. Ethanolamine phosphate phospholyase (ETNPPL), a newly discovered metabolic enzyme that converts phosphoethanolamine (PEA) to ammonia, inorganic… read more here.
Keywords: pi3k akt; sik1; inactivation; hyperinsulinemia induced ... See more keywords
Evidence of muscle loss delay and improvement of hyperinsulinemia and insulin resistance in Duchenne muscular dystrophy supplemented with omega-3 fatty acids: A randomized study.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2018.10.017
Abstract: BACKGROUND & AIMS Duchenne Muscular Dystrophy (DMD) is the most prevalent dystrophy of childhood and is characterized by generalized motor delays due to progressive muscular weakness, leading to loss of muscle mass. Additionally, patients with… read more here.
Keywords: hyperinsulinemia; loss; mass; study ... See more keywords
Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.09.001
Abstract: Hyperinsulinemia activates brain Akt and PKC-λ/ι and increases Aβ1-40/42 and phospho-tau in insulin-resistant animals. Here, we examined underlying mechanisms in mice, neuronal cells, and mouse hippocampal slices. Like Aβ1-40/42, β-secretase activity was increased in insulin-resistant… read more here.
Keywords: neuronal cells; hyperinsulinemia; pkc; brain ... See more keywords
Higher scores of dietary and lifestyle inflammatory indices are associated with increased risk of insulin-related disorders in Iranian adults
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Nutrition"
DOI: 10.1038/s41430-022-01143-0
Abstract: The roles of potential inflammation of diet and lifestyle in the risk of insulin-related disorders are unclear. In the current study, we aimed to assess the relationship between dietary inflammation scores (DIS), lifestyle inflammation scores… read more here.
Keywords: insulin related; score; risk; related disorders ... See more keywords
Role for insulin sensitivity in the cerebrovascular response to hyperinsulinemia in young adults
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731769
Abstract: Objective: Cerebral blood flow is highly regulated and cerebrovascular responsiveness to vasodilatory stimuli is predictive of brain health. In preclinical animal models, insulin elicits cerebrovascular dilation and subsequent increases in cerebral blood flow. Contrary to… read more here.
Keywords: physiology; insulin sensitivity; blood; hyperinsulinemia ... See more keywords
The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.162382
Abstract: Metabolic crosstalk from skeletal muscle to multiple organs is important for maintaining homeostasis, and its dysregulation can lead to various diseases. Chronic glucocorticoid administration often induces muscle atrophy and metabolic disorders such as diabetes and… read more here.
Keywords: crucial role; glucocorticoid; muscle signaling; muscle ... See more keywords
Role of Endothelin-1 Receptors in Limiting Leg Blood Flow and Glucose Uptake during Hyperinsulinemia in Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac008
Abstract: Skeletal muscle insulin resistance is a hallmark of individuals with type 2 diabetes mellitus (T2D). In healthy individuals insulin stimulates vasodilation, which is markedly blunted in T2D; however, the mechanism(s) remain incompletely understood. Investigations in… read more here.
Keywords: leg; eta receptor; type diabetes; glucose uptake ... See more keywords
Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin.
Sign Up to like & getrecommendations! Published in 2021 at "Cutis"
DOI: 10.12788/cutis.0173
Abstract: Hyperglycemia is defined by excess blood glucose and, when persistent, may lead to prediabetic and diabetic states. Insulin is a hormone produced by the beta cells of the pancreas in response to elevated blood glucose.… read more here.
Keywords: cutaneous manifestations; manifestations nutritional; hyperinsulinemia; skin ... See more keywords
Acute effects of euglycemic‐hyperinsulinemia on myocardial contractility in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15388
Abstract: Type 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve. However, the direct effects of hyperinsulinemia on… read more here.
Keywords: hyperinsulinemia myocardial; hemodynamics; adrenergic stimulation; stimulation ... See more keywords
Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes care"
DOI: 10.2337/dc21-2210
Abstract: OBJECTIVE The carbohydrate-insulin model (CIM) claims that chronic exposure to hyperinsulinemia induced by dietary carbohydrates explains development of obesity via direct effects of insulin and/or low postprandial metabolic fuel levels. We aimed at testing whether… read more here.
Keywords: obesity; insulin; associated greater; degree obesity ... See more keywords