Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1084
Abstract: Insulin aspart is a short‐acting insulin analogue that is used to control postprandial glycemia levels in diabetic patients. The aim of this clinical trial was to compare the pharmacokinetics and pharmacodynamics of GP40071 (GP‐Asp) and… read more here.
Keywords: clinical pharmacology; pharmacology; insulin aspart; hyperinsulinemic euglycemic ... See more keywords
Targeted lipidomics reveals associations between serum sphingolipids and insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2021.108699
Abstract: AIMS Sphingolipids(SPs) and their substrates and constituents, fatty acids (FAs), are implicated in the pathogenesis of various metabolic diseases associated. This study aimed to systematically investigate the associations between serum sphingolipids and insulin sensitivity as… read more here.
Keywords: associations serum; hyperinsulinemic euglycemic; euglycemic clamp; sensitivity ... See more keywords
Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2025.1568145
Abstract: Objective We sought to measure skeletal muscle microvascular hemodynamic responses in Sprague Dawley (SD) and Zucker Diabetic Sprague Dawley (ZDSD) rat model of type 2 diabetes (T2D) at rest and during a hyperinsulinemic-euglycemic clamp under… read more here.
Keywords: microvascular hemodynamic; clamp; hemodynamic responses; zdsd rats ... See more keywords