F-18 DOPA PET/CT in pediatric patients with hyperinsulinemic hypoglycemia: A correlation with genetic analysis
Sign Up to like & getrecommendations! Published in 2022 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001526
Abstract: Aim Persistent hyperinsulinemic hypoglycemia is a rare but life-threatening disease of infancy and childhood. 18F-DOPA PET/CT has been shown to be a useful modality in the localization of focal pancreatic lesions in these patients. We… read more here.
Keywords: hyperinsulinemic hypoglycemia; dopa pet; 18f dopa; dopa ... See more keywords
A family in which people with a heterozygous ABCC8 gene mutation (p.Lys1385Gln) have progressed from hyperinsulinemic hypoglycemia to hyperglycemia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.12990
Abstract: Funding information Japan Society for the Promotion of Science, Grant/Award Number: JP17K09842 Highlights • Inactivating mutations of the ABCC8 gene usually cause hyperinsulinemic hypoglycemia. • We report a family in which people with the inactivating… read more here.
Keywords: abcc8 gene; hypoglycemia; progressed hyperinsulinemic; family people ... See more keywords
Comparative meta-analysis of Kabuki syndrome with and without hyperinsulinemic hypoglycemia.
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DOI: 10.1111/cen.14267
Abstract: BACKGROUND AND OBJECTIVE Kabuki syndrome (KS), caused by pathogenic variants in KMT2D or KDM6A, is associated with hyperinsulinemic hypoglycemia (HH) in 0.3-4% of patients. We characterized the clinical, biochemical and molecular data of children with… read more here.
Keywords: hyperinsulinemic hypoglycemia; kabuki syndrome; meta; meta analysis ... See more keywords
Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017–2018): Congenital hyperinsulinism, insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s disease)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13180
Abstract: We aimed to investigate the nationwide incidence, treatment details and outcomes of patients with endogenous hyperinsulinemic hypoglycemia (EHH), including those with transient/persistent congenital hyperinsulinism (CHI), insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s… read more here.
Keywords: non insulinoma; hypoglycemia; endogenous hyperinsulinemic; insulinoma non ... See more keywords
Portosystemic shunt as a cause of congenital hyperinsulinemic hypoglycemia
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DOI: 10.1111/ped.13245
Abstract: Congenital hyperinsulinemic hypoglycemia (CHH) is characterized by the inappropriate secretion of insulin from pancreatic beta cells in the presence of hypoglycemia. We herein describe the case of a 5‐month‐old boy with CHH due to congenital… read more here.
Keywords: insulin; hypoglycemia; congenital hyperinsulinemic; portosystemic shunt ... See more keywords
Epileptic phenotype in late-onset hyperinsulinemic hypoglycemia successfully treated by diazoxide
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2020-0381
Abstract: Abstract Objectives Serious hyperinsulinemic hypoglycemia (HH) is generally the main initial symptom of hyperinsulinism. Epilepsy, without any overt feature of hypoglycemia, might be a very rare initial presentation of late-onset isolated hyperinsulinism. Case presentation We… read more here.
Keywords: late onset; hypoglycemia; epileptic phenotype; phenotype late ... See more keywords
Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333–3335
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes Care"
DOI: 10.2337/dc19-er07
Abstract: On page 3335 of the article cited above, funding information was added for author Frances M. Ashcroft. … read more here.
Keywords: neonatal hyperinsulinemic; erratum fetal; hyperinsulinemic hypoglycemia; macrosomia neonatal ... See more keywords
The Role of GLP-1 Signaling in Hypoglycemia due to Hyperinsulinism
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DOI: 10.3389/fendo.2022.863184
Abstract: Incretin hormones play an important role in the regulation of glucose homeostasis through their actions on the beta cells and other tissues. Glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are the two main… read more here.
Keywords: glp; hyperinsulinemic hypoglycemia; role; hypoglycemia ... See more keywords
Hyperinsulinemic Hypoglycemia Associated with a CaV1.2 Variant with Mixed Gain- and Loss-of-Function Effects
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DOI: 10.3390/ijms23158097
Abstract: The voltage-dependent L-type calcium channel isoform CaV1.2 is critically involved in many physiological processes, e.g., in cardiac action potential formation, electromechanical coupling and regulation of insulin secretion by beta cells. Gain-of-function mutations in the calcium… read more here.
Keywords: function; loss function; gain loss; hyperinsulinemic hypoglycemia ... See more keywords
Transient Hyperinsulinemic Hypoglycemia Linked to PAX6 Mutation
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DOI: 10.3390/medicina57060582
Abstract: Prolonged hyperinsulinemic hypoglycemia in infancy can result in developmental sequelae. A mutation in the paired box-6 gene (PAX6) has been reported to cause disorders in oculogenesis and neurogenesis. A limited number of cases of diabetes… read more here.
Keywords: pax6 mutation; hypoglycemia linked; transient hyperinsulinemic; hyperinsulinemic hypoglycemia ... See more keywords
Carcinoid Syndrome and Hyperinsulinemic Hypoglycemia Associated with Neuroendocrine Neoplasms: A Critical Review on Clinical and Pharmacological Management
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DOI: 10.3390/ph14060539
Abstract: The carcinoid syndrome (CS) and hyperinsulinemic hypoglycemia (HH) represent two of the most common clinical syndromes associated with neuroendocrine neoplasms (NENs). The former is mainly related to the serotonin secretion by a small bowel NEN,… read more here.
Keywords: neuroendocrine neoplasms; carcinoid syndrome; management; associated neuroendocrine ... See more keywords