Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34495
Abstract: Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group,… read more here.
Keywords: cytogenetically normal; acute myeloid; myeloid leukemia; hyperleukocytosis ... See more keywords
Clinical characteristics and outcomes of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis managed with different cytoreductive methods
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34751
Abstract: Hyperleukocytosis in patients with acute myeloid leukemia (AML) has been associated with worse outcomes. For cytoreduction, leukapheresis has been used but its clinical utility is unknown, and low‐dose cytarabine (LD‐cytarabine) is used as an alternative… read more here.
Keywords: myeloid leukemia; characteristics outcomes; acute myeloid; hyperleukocytosis ... See more keywords
Benefit of point of care testing in patient with major hyperleukocytosis.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2018.12.011
Abstract: We report a case of a child with major leukocytosis (800 × 109/L) leading to a false increase in plasma potassium and an unexpected spurious decrease in sodium. To suppress interferences due to hyperleukocytosis, our laboratory protocol… read more here.
Keywords: point care; interference; lysis; hyperleukocytosis ... See more keywords
Extensive intracranial haemorrhage as a complication of acute lymphoblastic leukaemia with hyperleukocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.03.056
Abstract: We report a rare case of distinctive extensive punctate intracranial haemorrhage associated with acute lymphoblastic leukaemia with hyperleukocytosis. A 7-year-old girl presented with hyperleukocytosis (white cell count 788.7 × 109/L; 94% peripheral blasts) and laboratory tumour lysis… read more here.
Keywords: lymphoblastic leukaemia; intracranial haemorrhage; acute lymphoblastic; hyperleukocytosis ... See more keywords
Real and spurious hypoxemia in a patient with extreme hyperleukocytosis.
Sign Up to like & getrecommendations! Published in 2017 at "Medicina intensiva"
DOI: 10.1016/j.medin.2017.10.006
Abstract: Hyperleukocytosis can cause respiratory failure due to pulmonary leukostasis. Additionally, gas tests can confirm the presence of pseudo-hypoxemia and the patient may end up receiving unnecessary treatments if undiagnosed. We hereby present the case of… read more here.
Keywords: hyperleukocytosis; blood; hypoxemia patient; respiratory failure ... See more keywords
Intracranial Hemorrhage Associated With T-Cell Acute Lymphoblastic Leukemia With Hyperleukocytosis: A Case Report
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002027
Abstract: Acute leukemia in children may present with hyperleukocytosis. Symptomatic hyperleukocytosis is a medical emergency that necessitates rapid stabilization of the patient and prompt lowering of the leukocyte count. We report on a patient with intracranial… read more here.
Keywords: leukemia; acute lymphoblastic; cell acute; lymphoblastic leukemia ... See more keywords
Hyperleukocytosis in infant acute leukemia: a role for manual exchange transfusion for leukoreduction
Sign Up to like & getrecommendations! Published in 2018 at "Transfusion"
DOI: 10.1111/trf.14512
Abstract: Hyperleukocytosis is a serious, life‐threatening complication of pediatric acute leukemia that can cause neurologic injury, pulmonary leukostasis, metabolic derangements, and coagulopathy. Acute leukemia has the highest risk of mortality and morbidity at presentation when associated… read more here.
Keywords: hyperleukocytosis infant; hyperleukocytosis; acute leukemia; leukemia ... See more keywords
Lipegfilgrastim may cause hyperleukocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552221082645
Abstract: Introduction Granulocyte colony-stimulating factors (G-CSF) are utilized both in the treatment and prophylaxis of chemotherapy-induced neutropenia. Lipegfilgrastim is a long-acting G-CSF. Albeit it provides ease of administration compared to short-acting GCSFs, some lipegfilgrastim-related adverse events… read more here.
Keywords: cause hyperleukocytosis; lipegfilgrastim; may occur; may cause ... See more keywords
Leukapheresis and Hyperleukocytosis, Past and Future
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s321787
Abstract: Abstract Hyperleukocytosis is a hematologic crisis caused by excessive proliferation of leukemic cells and has a relatively high early mortality due to a series of severe complications. Therefore, prompt and effective intervention is required. Leukapheresis… read more here.
Keywords: medicine; past future; hyperleukocytosis past; leukapheresis hyperleukocytosis ... See more keywords