Density Control over MBD2 Receptor-Coated Surfaces Provides Superselective Binding of Hypermethylated DNA
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c09641
Abstract: Using the biomarker hypermethylated DNA (hmDNA) for cancer detection requires a pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity chromatography using a methyl binding domain-2 (MBD2) protein can be used, but the relatively… read more here.
Keywords: control mbd2; hypermethylated dna; receptor; density control ... See more keywords
Hypermethylated DNA, a circulating biomarker for colorectal cancer detection
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180809
Abstract: Background Colorectal cancer (CRC) is one of the most common cancers in the western world. Screening is an efficient method of reducing cancer-related mortality. Molecular biomarkers for cancer in general and CRC in particular have… read more here.
Keywords: hypermethylated dna; detection; promoter regions; crc ... See more keywords