NKX6.1 hypermethylation predicts the outcome of stage II colorectal cancer patients undergoing chemotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1002/gcc.22529
Abstract: Colorectal cancer (CRC) is a common malignancy worldwide. CRC patients in the same stage often present with dramatically different clinical scenarios. Thus, robust prognostic biomarkers are urgently needed to guide therapies and improve treatment outcomes.… read more here.
Keywords: chemotherapy; methylation; hypermethylation; crc ... See more keywords
Noninvasive diagnosis of urothelial cancer in urine using DNA hypermethylation signatures—Gender matters
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32356
Abstract: Urothelial cancer (UCa) is the most predominant cancer of the urinary tract and noninvasive diagnosis using hypermethylation signatures in urinary cells is promising. Here, we assess gender differences in a newly identified set of methylation… read more here.
Keywords: methylation; urothelial cancer; hypermethylation; noninvasive diagnosis ... See more keywords
Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy
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DOI: 10.1002/jcb.25841
Abstract: A detrimental consequence of hypermethylation is hyperhomocysteinemia (HHcy), that causes oxidative stress, inflammation, and matrix degradation, which leads to multi‐pathology in different organs. Although, it is well known that hypermethylation leads to overall gene silencing… read more here.
Keywords: skeletal muscle; hhcy; muscle; hypermethylation ... See more keywords
Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue
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DOI: 10.1007/s00428-017-2094-2
Abstract: The present study was undertaken to explore and validate novel hypermethylated DNA regions in squamous cell carcinoma of the tongue (SCCT). Genome-wide methylation changes were identified by differential methylation hybridization (DMH) microarray and validated by… read more here.
Keywords: cell carcinoma; squamous cell; hypermethylation; promoter ... See more keywords
Hypermethylation of NF-κB-Activating Protein-Like (NKAPL) Promoter in Hepatocellular Carcinoma Suppresses Its Expression and Predicts a Poor Prognosis
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-4929-3
Abstract: Background and AimHepatocellular carcinoma (HCC) is a complicated disease with low survival rate partially due to frequent recurrence and no efficient therapy. Promoter hypermethylation of tumor suppressor genes has been demonstrated as one of the… read more here.
Keywords: methylation; hcc; hypermethylation; nkapl hcc ... See more keywords
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
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DOI: 10.1016/j.celrep.2020.03.022
Abstract: Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose patients to aggressive tumors characterized by pseudohypoxic and hypermethylator phenotypes. The mechanisms leading to DNA hypermethylation and its contribution to SDH-deficient cancers remain undemonstrated. We examine the… read more here.
Keywords: sdh deficient; hypermethylation; mediated hypermethylation; tet mediated ... See more keywords
TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.03.001
Abstract: Long term exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with the increasing risk of lung cancer. To identify differentially hypermethylated genes associated with PAHs-induced carcinogenicity, we performed genome-wide DNA methylation analysis in 20 μM benzo(a)pyrene… read more here.
Keywords: hypermethylation; aromatic hydrocarbons; cell transformation; trim36 hypermethylation ... See more keywords
Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2020.106887
Abstract: Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders and manifests inattention, hyperactivity, and impulsivity symptoms in childhood that can last throughout life. Genetic and environmental studies implicate the dopamine system in… read more here.
Keywords: deltamethrin corticosterone; midbrain; hypermethylation; exposure ... See more keywords
MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility
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DOI: 10.1016/j.tranon.2016.11.006
Abstract: Epigenetic silencing by DNA methylation in brain tumors has been reported for many genes, however, their function on pathogenesis needs to be evaluated. We investigated the MTSS1 gene, identified as hypermethylated by differential methylation hybridization… read more here.
Keywords: glioma; cell motility; hypermethylation; mtss1 ... See more keywords
Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2017.03.004
Abstract: &NA; Atrial fibrillation (AF) is the most common cardiac arrhythmia. As the molecular mechanisms underlying the pathology are largely unknown, this cardiac arrhythmia remains difficult to treat. To identify specific molecular actors involved in AF,… read more here.
Keywords: atrial fibrillation; spontaneously hypertensive; hypertensive rats; hypermethylation ... See more keywords
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma
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DOI: 10.1038/s10038-020-0736-8
Abstract: This study is intended to investigate the epigenetic regulation of the most conserved molecular chaperone, HSP70 and its potential role in the pathophysiology of pseudoexfoliation syndrome (PEXS) and glaucoma (PEXG), a protein aggregopathy, contributing significantly… read more here.
Keywords: hsp70; hypermethylation; pexs; pseudoexfoliation syndrome ... See more keywords