Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation
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DOI: 10.1038/s41598-018-27930-z
Abstract: Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations),… read more here.
Keywords: mitochondrial dna; hypermutation; keratinocyte differentiation;
Post‐treatment hypermutation in a recurrent diffuse glioma with H3.3 p.G34 Mutation
Sign Up to like & getrecommendations! Published in 2020 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12679
Abstract: Diffuse gliomas with H3F3A point mutations affecting histone H3.3 glycine position 34 are a distinct glioma subtype mostly occurring in the cerebral hemispheres of paediatric and young adult patients. These tumours have a high rate… read more here.
Keywords: post treatment; diffuse; glioma; hypermutation ... See more keywords
Methylation-Induced Hypermutation in Natural Populations of Bacteria
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bacteriology"
DOI: 10.1128/jb.00371-18
Abstract: A common type of DNA modification, addition of a methyl group to cytosine (C) at carbon atom C-5, can greatly increase the rate of mutation of the C to a T. In mammals, methylation of… read more here.
Keywords: methylation; mutation rate; rate; hypermutation ... See more keywords
Abstract 4091: Knockout of genes in the DNA mismatch repair pathway to model colorectal cancer hypermutation
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4091
Abstract: Human colorectal cancer (CRC) is characterized by a high burden of somatic mutations, particularly in tumors harboring defects in the DNA mismatch repair (MMR) pathway. However, genetically-engineered mouse models (GEMMs) of cancer to date harbor… read more here.
Keywords: dna mismatch; colorectal cancer; crc; cancer ... See more keywords
Abstract 5705: Mechanisms and therapeutic implications of hypermutation in gliomas
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-5705
Abstract: High tumor mutational burden (hypermutation) is observed in some gliomas; however, its mechanisms of development and whether it predicts immunotherapy response are poorly understood. Here, we comprehensively analyze the molecular determinants of mutational burden and… read more here.
Keywords: gliomas; implications hypermutation; mechanisms therapeutic; therapeutic implications ... See more keywords
Clinical and morphological characterization for detection of hypermutation in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15647
Abstract: e15647Background: Hypermutation, which is a molecular subtype with high tumor mutation burden (TMB), has been recognized as a biomarker of anti-PD-1 therapy in many cancers. Hypermutation can be de... read more here.
Keywords: detection hypermutation; clinical morphological; characterization detection; hypermutation ... See more keywords
Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
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DOI: 10.1371/journal.pbio.3000464
Abstract: A single cancer genome can harbor thousands of clustered mutations. Mutation signature analyses have revealed that the origin of clusters are lesions in long tracts of single-stranded (ss) DNA damaged by apolipoprotein B mRNA editing… read more here.
Keywords: genome wide; strand breaks; double strand; cancer ... See more keywords
Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli
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DOI: 10.1371/journal.pone.0178303
Abstract: Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E. coli, the SOS… read more here.
Keywords: response; zinc; sos response; coli ... See more keywords
The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.943346
Abstract: Chronic respiratory infection (CRI) with Pseudomonas aeruginosa (Pa) presents many unique challenges that complicate treatment. One notable challenge is the hypermutator phenotype which is present in up to 60% of sampled CRI patient isolates. Hypermutation… read more here.
Keywords: pseudomonas aeruginosa; respiratory infection; infection; virulence ... See more keywords
Rapid Hypermutation B Cell Trajectory Recruits Previously Primed B Cells Upon Third SARS-Cov-2 mRNA Vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.876306
Abstract: High antibody affinity against the ancestral SARS-CoV-2 strain seems to be necessary (but not always sufficient) for the control of emerging immune-escape variants. Therefore, aiming at strong B cell somatic hypermutation - not only at… read more here.
Keywords: cell; vaccination; somatic hypermutation; immune escape ... See more keywords
Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display
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DOI: 10.3390/antib7040042
Abstract: The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation. Several antibody affinity maturation systems based on mammalian cells… read more here.
Keywords: antibody; antibody affinity; aid; hypermutation ... See more keywords