TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons
Sign Up to like & getrecommendations! Published in 2024 at "Cell Discovery"
DOI: 10.1038/s41421-023-00628-x
Abstract: Thirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be life-threatening. Interoceptive neurons in the subfornical organ (SFO) are intrinsically osmosensitive and their activation by hyperosmolarity is necessary… read more here.
Keywords: tmem63b channel; osmosensor required; hyperosmolarity; osmosensor ... See more keywords
Copolymer Micelle-administered Melatonin Ameliorates Hyperosmolarity-induced Ocular Surface Damage through Regulating PINK1-mediated Mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Current Eye Research"
DOI: 10.1080/02713683.2021.2022163
Abstract: Abstract Purpose To investigate the role and mechanism of melatonin-loaded polymer polyvinyl caprolactam–polyvinyl acetate–polyethyleneglycol graft copolymer micelles (Mel-Mic) in dry eye disease (DED). Methods In vitro, the apoptosis and reactive oxygen species (ROS) generation in… read more here.
Keywords: induced ocular; ameliorates hyperosmolarity; hyperosmolarity induced; hyperosmolarity ... See more keywords
Characterization of the proteome changes in an in vitro hyperosmotic dry eye model employing human corneal epithelial cells
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.16032
Abstract: Aims/Purpose: The detrimental effects of tear hyperosmolarity on human corneal epithelial (HCE) cells is a primary cause of dry eye syndrome (DES). However, the molecular mechanisms underlying inflammatory processes and cellular dysfunction in HCE are… read more here.
Keywords: hyperosmolarity; human corneal; corneal epithelial; cell ... See more keywords
Edaravone protects against hyperosmolarity-induced oxidative stress and apoptosis in primary human corneal epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0174437
Abstract: An increase in the osmolarity of tears induced by excessive evaporation of the aqueous tear phase is a major pathological mechanism behind dry eye. Exposure of epithelial cells on the surface of the human eye… read more here.
Keywords: epithelial cells; apoptosis; hyperosmolarity induced; hyperosmolarity ... See more keywords
Hyperosmolarity Deserves More Attention in Critically Ill COVID-19 Patients with Diabetes: A Cohort-Based Study
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s284148
Abstract: Purpose Recently, a cluster of pneumonia caused by SARS-CoV-2 were identified in Wuhan and spread throughout the world. More information about risk factors for mortality of critically ill patients infected with SARS-CoV-2 remain to be… read more here.
Keywords: ill patients; odds ratio; critically ill; patients diabetes ... See more keywords
Hyperosmolarity Impairs Human Extravillous Trophoblast Differentiation by Caveolae Internalization
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.760163
Abstract: We recently reported that an intact caveolar structure is necessary for adequate cell migration and tubulogenesis of the human extravillous trophoblast (EVT) cells. Emerging evidence supports that hyperosmolarity induces the internalization of caveolae into the… read more here.
Keywords: differentiation; caveolae; trophoblast; hyperosmolarity ... See more keywords