Hyperoxia exposure disrupts adrenomedullin signaling in newborn mice: Implications for lung development in premature infants.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.112
Abstract: Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of human infants that is characterized by disrupted lung angiogenesis. Adrenomedullin (AM) is a multifunctional peptide with angiogenic and vasoprotective properties. AM… read more here.
Keywords: hyperoxia exposure; neonatal mice; mice; lung development ... See more keywords
CPAP PROTECTS AGAINST HYPEROXIA-INDUCED INCREASE IN AIRWAY REACTIVITY IN NEONATAL MICE
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric research"
DOI: 10.1038/s41390-020-01212-9
Abstract: Oxygen and continuous positive airway pressure (CPAP) are primary modes of respiratory support for preterm infants. Animal models, however, have demonstrated adverse unintended effects of hyperoxia and CPAP on lung development. We investigate the effects… read more here.
Keywords: cpap hyperoxia; hyperoxia; hyperoxia exposure; cpap ... See more keywords
Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Reports"
DOI: 10.14814/phy2.14334
Abstract: Supplemental oxygen (O2) therapy in preterm infants impairs lung development, but the impact of O2 on long‐term systemic vascular structure and function has not been well‐explored. The present study tested the hypothesis that neonatal O2… read more here.
Keywords: function; biomechanical alterations; hyperoxia exposure; neonatal hyperoxia ... See more keywords
The Specific Connexin 43–Inhibiting Peptide Gap26 Improved Alveolar Development of Neonatal Rats With Hyperoxia Exposure
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.587267
Abstract: Bronchopulmonary dysplasia (BPD) is a common devastating pulmonary complication in preterm infants. Alveolar maldevelopment is the crucial pathological change of BPD highly associated with oxidative stress–mediated excessive apoptosis. Cellular injury can be propagated and amplified… read more here.
Keywords: gap26; apoptosis; hyperoxia exposure; intercellular communication ... See more keywords
An Inexpensive Open-Source Chamber for Controlled Hypoxia/Hyperoxia Exposure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.891005
Abstract: Understanding hypoxia/hyperoxia exposure requires either a high-altitude research facility or a chamber in which gas concentrations are precisely and reproducibly controlled. Hypoxia-induced conditions such as hypoxic-ischemic encephalopathy (HIE), obstructive or central apneas, and ischemic stroke… read more here.
Keywords: chamber; hypoxia hyperoxia; hypoxia; hyperoxia exposure ... See more keywords
Kidney Injuries and Evolution of Chronic Kidney Diseases Due to Neonatal Hyperoxia Exposure Based on Animal Studies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158492
Abstract: Preterm birth interrupts the development and maturation of the kidneys during the critical growth period. The kidneys can also exhibit structural defects and functional impairment due to hyperoxia, as demonstrated by various animal studies. Furthermore,… read more here.
Keywords: kidney injuries; kidney; chronic kidney; hyperoxia exposure ... See more keywords