Effects of nebulized N‐acetylcystein on the expression of HMGB1 and RAGE in rats with hyperoxia‐induced lung injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27724
Abstract: To investigate the role of high mobility group box 1 (HMGB1) and receptor for advanced glycation end product (RAGE) in the lungs of hyperoxia‐induced rats and the effect of N‐acetlycystein (NAC). read more here.
Keywords: hmgb1; hyperoxia induced; effects nebulized; rage ... See more keywords
Rho‐kinase inhibitors protect against neonatal hyperoxia‐induced airway hyperreactivity in a rat pup model: Role of prostaglandin F2α
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.25848
Abstract: Oxygen therapy in preterm neonates is associated with airway hyperreactivity. The role of Rho/Rho‐kinase smooth muscle signaling in hyperoxia‐induced airway hyperreactivity remains understudied. We hypothesized that inhibition of Rho‐kinase will attenuate airway hyperreactivity induced by… read more here.
Keywords: hyperoxia induced; rho kinase; induced airway; airway hyperreactivity ... See more keywords
Role of Fatty Acid Oxidation in Hyperoxia-induced Apoptosis in Neonatal Lung Endothelial Cells: Implications for Lung Injury and Repair
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.281
Abstract: In neonates, hyperoxia causes lung injury characterized by impaired vascularization and alveolarization. These are the hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants with long-term sequelae. The pulmonary vascular bed is… read more here.
Keywords: hyperoxia induced; hyperoxia; air; lung injury ... See more keywords
Activation of NF-KB in Airway Epithelia Protects Against Hyperoxia-Induced Proinflammatory Lung Injury
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.210
Abstract: Hyperoxia-induced acute lung injury (HALI) during mechanical ventilation can lead to excessive proinflammatory responses, endothelial and epithelial cell damage, and alveolar edema. We and others have demonstrated that NF-kB activation has a protective effect on… read more here.
Keywords: activation airway; lung injury; hyperoxia induced; lung ... See more keywords
Roxadustat attenuates hyperoxia-induced lung injury by upregulating proangiogenic factors in newborn mice.
Sign Up to like & getrecommendations! Published in 2021 at "Pediatrics and neonatology"
DOI: 10.1016/j.pedneo.2021.03.012
Abstract: BACKGROUND Premature infants who require oxygen therapy for respiratory distress syndrome often develop bronchopulmonary dysplasia, a chronic lung disease characterized by interrupted alveologenesis. Disrupted angiogenesis inhibits alveologenesis; however, the mechanisms through which disrupted angiogenesis affects… read more here.
Keywords: hyperoxia induced; angiogenesis; induced lung; lung injury ... See more keywords
Maternal antibiotic exposure disrupts microbiota and exacerbates hyperoxia-induced lung injury in neonatal mice
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Research"
DOI: 10.1038/s41390-020-01335-z
Abstract: Background Perinatal antibiotic treatment alters intestinal microbiota and augments hyperoxia-induced lung injury in mice offspring. The effect of maternal antibiotic treatment (MAT) during pregnancy on the lung microbiota and its relationship with lung injury remains… read more here.
Keywords: hyperoxia induced; neonatal hyperoxia; hyperoxia; lung injury ... See more keywords
The mechanism of hyperoxia-induced neonatal renal injury and the possible protective effect of Resveratrol.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of perinatology"
DOI: 10.1055/a-1817-5357
Abstract: With recent advances in neonatal intensive care, preterm infants are surviving into adulthood. Nonetheless,epidemiological data on the health status of these preterm infants has begun to reveal a worrying theme; prematurity and the supplemental oxygen… read more here.
Keywords: hyperoxia induced; renal injury; disease; mechanism ... See more keywords
Prevalence and mechanisms of environmental hyperoxia-induced thermal tolerance in fishes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2022.0840
Abstract: Recent evidence has suggested environmental hyperoxia (O2 supersaturation) can boost cardiorespiratory performance in aquatic ectotherms, thereby increasing resilience to extreme heat waves associated with climate change. Here, using rainbow trout (Oncorhynchus mykiss) as a model… read more here.
Keywords: hyperoxia induced; environmental hyperoxia; induced thermal; thermal tolerance ... See more keywords
Umbilical Cord Blood-derived Exosomes from Healthy Term Pregnancies Protect against Hyperoxia-induced Lung Injury in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13502
Abstract: Bronchopulmonary dysplasia (BPD) is a chronic, devastating disease primarily occurring in premature infants. To date, intervention strategies to prevent or treat BPD are limited. We aimed to determine the effects of umbilical cord blood-derived exosomes… read more here.
Keywords: hyperoxia induced; lung injury; induced lung; mice ... See more keywords
Mesenchymal stem cells from different sources show distinct therapeutic effects in hyperoxia‐induced bronchopulmonary dysplasia in rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16817
Abstract: Mesenchymal stem cells (MSCs) have been shown as an effective medicinal means to treat bronchopulmonary dysplasia (BPD). The widely used MSCs were from Wharton's jelly of umbilical cord (UC‐MSCs) and bone marrow (BM‐MSCs). Amniotic fluid… read more here.
Keywords: bronchopulmonary dysplasia; hyperoxia induced; therapeutic effects; mscs ... See more keywords
The effects of bosentan on hyperoxia‐induced lung injury in neonatal rats
Sign Up to like & getrecommendations! Published in 2019 at "Pediatrics International"
DOI: 10.1111/ped.14013
Abstract: Bronchopulmonary dysplasia (BPD) remains an important cause of morbidity and mortality in premature infants. There is currently no proven effective treatment modality for BPD, and inflammation and oxidative injury play an important role in the… read more here.
Keywords: effects bosentan; hyperoxia induced; induced lung; lung injury ... See more keywords