Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho.
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DOI: 10.1681/asn.2015111266
Abstract: αKlotho (αKL) regulates mineral metabolism, and diseases associated with αKL deficiency are characterized by hyperphosphatemia and vascular calcification (VC). αKL is expressed as a membrane-bound protein (mKL) and recognized as the coreceptor for fibroblast growth… read more here.
Keywords: null mice; vascular calcification; ckl; hyperphosphatemia vascular ... See more keywords