Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500941
Abstract: Tau hyperphosphorylation represents a critical pathological hallmark of Alzheimer's disease (AD), a prevalent neurodegenerative disorder characterized by progressive cognitive decline. The ubiquitin‐specific proteases 14 (USP14) impairs proteasomal function and accelerates hyperphosphorylated Tau accumulation, making it… read more here.
Keywords: alzheimer disease; synaptic integrity; tau hyperphosphorylation; hyperphosphorylation ... See more keywords
Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease.
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DOI: 10.1002/advs.202509773
Abstract: Tau aggregation plays a critical role in Alzheimer's Disease (AD), where neurofibrillary tangles (NFTs) are a pathological hallmark. While much attention is given to NFTs, emerging evidence highlights nano-sized tau oligomers as toxic entities. Using… read more here.
Keywords: alzheimer disease; nano aggregates; nanoscale tau; tau aggregates ... See more keywords
Natural products against tau hyperphosphorylation‐induced aggregates: Potential therapies for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2025 at "Archiv Der Pharmazie"
DOI: 10.1002/ardp.202400721
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairments and is considered the most prevalent form of dementia. Among the contributing factors to AD lies the hyperphosphorylation of the… read more here.
Keywords: alzheimer disease; hyperphosphorylation induced; natural products; tau hyperphosphorylation ... See more keywords
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica"
DOI: 10.1007/s00401-025-02930-2
Abstract: Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occurs physiologically during mammalian hibernation and is fully reversed upon arousal, offering a unique translational model to study tau metabolism. However,… read more here.
Keywords: brain; tau; brain tissue; hibernation ... See more keywords
IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ25–35 peptide in PC12 cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-017-0550-8
Abstract: The primary features of Alzheimer’s disease (AD) are extracellular amyloid plaques consisting mainly of deposits of amyloid β (Aβ) peptides and intracellular neurofibrillary tangles (NFTs). Sets of evidence suggest that interleukin-5 (IL-5) is involved in… read more here.
Keywords: apoptosis tau; pc12 cells; blocks apoptosis; hyperphosphorylation ... See more keywords
Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2016.09.027
Abstract: A history of traumatic brain injury (TBI) is linked to an increased risk for the later development of dementia. This encompasses a variety of neurodegenerative diseases including Alzheimer's Disease (AD) and chronic traumatic encephalopathy (CTE),… read more here.
Keywords: dementia; brain; hyperphosphorylation; tbi ... See more keywords
Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.07.009
Abstract: BACKGROUND Hypertension-induced microvascular brain injury is a major vascular contributor to cognitive impairment and dementia. We hypothesized that chronic hypoxia promotes the hyperphosphorylation of tau and cell death in an accelerated spontaneously hypertensive stroke prone… read more here.
Keywords: dorsolateral cortex; hyperphosphorylation; vascular dysfunction; hypoxia promotes ... See more keywords
Neurons ensheathed by perineuronal nets are prone to hyperphosphorylation of tau protein in the hibernating Syrian hamster brain
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-14942-9
Abstract: Perineuronal nets (PNNs) are a specialized form of neuronal extracellular matrix that often ensheath highly active cells, such as parvalbumin-positive (PV+) interneurons. Net-bearing neurons have been shown to be devoid of pathological aggregates of hyperphosphorylated… read more here.
Keywords: tau protein; perineuronal nets; tau; hibernating syrian ... See more keywords
Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddw425
Abstract: Hereditary spastic paraplegia, SPG31, is a rare neurological disorder caused by mutations in REEP1 gene encoding the microtubule-interacting protein, REEP1. The mechanism by which REEP1-dependent processes are linked with the disease is unclear. REEP1 regulates… read more here.
Keywords: mitochondrial morphology; morphology; distribution; hyperphosphorylation ... See more keywords
Alzheimer’s disease: Ablating single master site abolishes tau hyperphosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl8809
Abstract: Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as Alzheimer’s disease. A central unanswered question is why tau becomes progressively hyperphosphorylated. Here, we show that tau phosphorylation is governed by… read more here.
Keywords: tau; alzheimer disease; master; site ... See more keywords
Serine 235 Is the Primary NS5A Hyperphosphorylation Site Responsible for Hepatitis C Virus Replication
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00194-17
Abstract: ABSTRACT The nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) is a phosphoprotein with two phosphorylation states: hypo- and hyperphosphorylation. Genetic mutation studies have demonstrated a cluster of serine residues responsible for NS5A… read more here.
Keywords: ns5a hyperphosphorylation; serine; hyperphosphorylation; replication ... See more keywords