DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03273-6
Abstract: Accumulating data suggest that the downregulation of DHCR24 is linked to the pathological risk factors of AD, denoting a potential role of DHCR24 in AD pathogenesis. However, it remains unclear whether the downregulation of DHCR24… read more here.
Keywords: hyperphosphorylation tau; dhcr24 knockdown; tau; pp2a ... See more keywords
HIF-1α is a “brake” in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells
Sign Up to like & getrecommendations! Published in 2024 at "Mycotoxin Research"
DOI: 10.1007/s12550-024-00525-6
Abstract: Mycotoxins have been shown to activate multiple mechanisms that may potentially lead to the progression of Alzheimer’s disease (AD). Overexpression/aberrant cleavage of amyloid precursor protein (APP) and hyperphosphorylation of tau (P-tau) is hallmark pathologies of… read more here.
Keywords: jnk; bv2 cells; tau; app tau ... See more keywords
Parkin is downregulated among autophagy-related proteins prior to hyperphosphorylation of Tau in TS65DN mice.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.016
Abstract: Autophagy is a pathway through which cells execute a plethora of functions, such as macromolecules and organelles quality control, recycling of building blocks and apoptosis. Numerous studies have shown in the past that autophagy is… read more here.
Keywords: related proteins; hyperphosphorylation tau; ts65dn mice; autophagy related ... See more keywords