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   Articles with "hyperpolarization" as a keyword



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Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid

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recommendations! Published in 2022 at "Chemphyschem"

DOI: 10.1002/cphc.202200274

Abstract: Abstract The reaction of unsaturated substrates with hydrogen gas enriched in the para spin isomer leads to products with a high degree of nuclear singlet spin order. This leads to greatly enhanced NMR signals, with… read more here.

Keywords: application; hyperpolarization; singlet; succinic acid ... See more keywords

SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss

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recommendations! Published in 2019 at "ChemistryOpen"

DOI: 10.1002/open.201900139

Abstract: Abstract The signal enhancement provided by the hyperpolarization of nuclear spins of biological molecules is a highly promising technique for diagnostic imaging. To date, most 13C‐contrast agents had to be polarized in an extra, complex… read more here.

Keywords: sambadena hyperpolarization; 13c succinate; hyperpolarization 13c; loss ... See more keywords
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Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior.

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recommendations! Published in 2018 at "Handbook of experimental pharmacology"

DOI: 10.1007/164_2017_90

Abstract: Neural mechanisms underlying alcohol use disorder remain elusive, and this lack of understanding has slowed the development of efficacious treatment strategies for reducing relapse rates and prolonging abstinence. While synaptic adaptations produced by chronic alcohol… read more here.

Keywords: potassium channels; hyperpolarization; intrinsic excitability; chronic alcohol ... See more keywords
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Artifactual hyperpolarization during extracellular electrical stimulation: Proposed mechanism of high-rate neuromodulation disproved

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recommendations! Published in 2018 at "Brain Stimulation"

DOI: 10.1016/j.brs.2017.12.004

Abstract: BACKGROUND Kilohertz-frequency electric field stimulation (kEFS) applied to the spinal cord can reduce chronic pain without causing the buzzing sensation (paresthesia) associated with activation of dorsal column fibers. This suggests that high-rate spinal cord stimulation… read more here.

Keywords: hyperpolarization; stimulation; patch clamp; extracellular electrical ... See more keywords
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Impaired cross-talk between NO and hyperpolarization in myoendothelial feedback: a novel therapeutic target in early endothelial dysfunction of metabolic disease.

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recommendations! Published in 2019 at "Current opinion in pharmacology"

DOI: 10.1016/j.coph.2019.03.007

Abstract: Over the past three decades, our view of the endothelium rapidly evolved from a static lining of the blood vessels to a dynamic determinant and regulator of vascular tone and homeostasis. It is now widely… read more here.

Keywords: hyperpolarization; metabolic disease; disease; function ... See more keywords
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Depolarization or hyperpolarization: Emerging role of altered bioelectricity in breast cancer metastasis

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recommendations! Published in 2022 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2022.103853

Abstract: eBioMedicine 2022;76: 103853 Published online xxx https://doi.org/10.1016/j. ebiom.2022.103853 Cell membrane potential (Em) is essential for electrical activities in excitable cells such as neurons and heart cells. Accumulating data has now revealed an important role of… read more here.

Keywords: cancer; hyperpolarization; depolarization; breast cancer ... See more keywords
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Analysis of Complex Mixtures by Chemosensing NMR Using para-Hydrogen-Induced Hyperpolarization

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recommendations! Published in 2022 at "Accounts of Chemical Research"

DOI: 10.1021/acs.accounts.1c00796

Abstract: Conspectus Nuclear magnetic resonance (NMR) is a powerful technique for chemical analysis. The use of NMR to investigate dilute analytes in complex systems is, however, hampered by its relatively low sensitivity. An additional obstacle is… read more here.

Keywords: para hydrogen; hyperpolarization; analysis; spin ... See more keywords
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Rapid 13C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c02160

Abstract: α-Ketoglutarate is a key biomolecule involved in a number of metabolic pathways─most notably the TCA cycle. Abnormal α-ketoglutarate metabolism has also been linked with cancer. Here, isotopic labeling was employed to synthesize [1-13C,5-12C,D4]α-ketoglutarate with the… read more here.

Keywords: sabre sheath; hyperpolarization; ketoglutarate; polarization ... See more keywords
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Modern Manufacturing Enables Magnetic Field Cycling Experiments and Parahydrogen-Induced Hyperpolarization with a Benchtop NMR.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c03682

Abstract: Benchtop NMR (btNMR) spectrometers are revolutionizing the way we use NMR and lowering the cost drastically. Magnetic field cycling (MFC) experiments with precise timing and control over the magnetic field, however, were hitherto not available… read more here.

Keywords: hyperpolarization; chemistry; nmr; magnetic field ... See more keywords
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Application of 15N2-Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP.

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recommendations! Published in 2020 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.0c00028

Abstract: 15N2-Diazirines represent an attractive class of imaging tags for hyperpolarized magnetic resonance imaging (HP-MRI), offering desirable biocompatibility, ease of incorporation into a variety of molecules, and ability to deliver long-lasting polarization. We have recently established… read more here.

Keywords: hyperpolarization; application 15n2; polarization; diazirines versatile ... See more keywords
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Spin Hyperpolarization in Modern Magnetic Resonance

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recommendations! Published in 2023 at "Chemical Reviews"

DOI: 10.1021/acs.chemrev.2c00534

Abstract: Magnetic resonance techniques are successfully utilized in a broad range of scientific disciplines and in various practical applications, with medical magnetic resonance imaging being the most widely known example. Currently, both fundamental and applied magnetic… read more here.

Keywords: magnetic resonance; hyperpolarization; hyperpolarization techniques; field ... See more keywords