Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1‐13C]pyruvate MRI
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DOI: 10.1002/jmri.28196
Abstract: Hyperpolarized 13C MRI quantitatively measures enzyme‐catalyzed metabolism in cancer and metabolic diseases. Whole‐abdomen imaging will permit dynamic metabolic imaging of several abdominal organs simultaneously in healthy and diseased subjects. read more here.
Keywords: abdomen metabolic; metabolic imaging; healthy volunteers; hyperpolarized 13c ... See more keywords
Direct arterial injection of hyperpolarized 13C‐labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution
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DOI: 10.1002/mrm.26628
Abstract: A rat model was developed to enable direct administration of hyperpolarized 13C‐labeled molecules into a tumor‐supplying artery for magnetic resonance spectroscopy (MRS) studies of tumor metabolism. read more here.
Keywords: arterial injection; metabolism; direct arterial; 13c labeled ... See more keywords
High resolution hyperpolarized 13C MRSI using SPICE at 9.4T
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DOI: 10.1002/mrm.27061
Abstract: To test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial separability of spectroscopic data, for high resolution hyperpolarized (HP) 13C spectroscopic imaging. read more here.
Keywords: high resolution; using spice; resolution hyperpolarized; 13c mrsi ... See more keywords
Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13C MR EPSI studies of liver tumors
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DOI: 10.1002/mrm.28901
Abstract: To develop a novel post‐processing pipeline for hyperpolarized (HP) 13C MRSI that integrates tensor denoising and B1+ correction to measure pyruvate‐to‐lactate conversion rates (kPL) in patients with liver tumors. read more here.
Keywords: specialized computational; liver tumors; denoising correction; hyperpolarized 13c ... See more keywords
Hyperpolarized 13C MRI Reveals Large Changes in Pyruvate Metabolism During Digestion in Snakes
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DOI: 10.1002/mrm.29239
Abstract: Hyperpolarized 13C MRI is a powerful technique to study dynamic metabolic processes in vivo; but it has predominantly been used in mammals, mostly humans, pigs, and rodents. read more here.
Keywords: reveals large; 13c mri; hyperpolarized 13c; large changes ... See more keywords
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13C,15N2]urea + [1‐13C]pyruvate simultaneous perfusion and metabolic imaging
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DOI: 10.1002/mrm.29266
Abstract: This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack‐of‐spiral balanced steady‐state free precession(3D‐bSSFP) urea sequence, interleaved with a metabolite‐specific gradient echo (GRE) sequence for pyruvate and metabolic products, for… read more here.
Keywords: magnetic resonance; hyperpolarized 13c; 15n2 urea; 13c 15n2 ... See more keywords
Kinetic analysis of multi‐resolution hyperpolarized 13C human brain MRI to study cerebral metabolism
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DOI: 10.1002/mrm.29354
Abstract: To investigate multi‐resolution hyperpolarized (HP) 13C pyruvate MRI for measuring kinetic conversion rates in the human brain. read more here.
Keywords: hyperpolarized 13c; human brain; mri; resolution hyperpolarized ... See more keywords
Model‐constrained reconstruction accelerated with Fourier‐based undersampling for hyperpolarized [1‐13C] pyruvate imaging
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DOI: 10.1002/mrm.29551
Abstract: Model‐constrained reconstruction with Fourier‐based undersampling (MoReFUn) is introduced to accelerate the acquisition of dynamic MRI using hyperpolarized [1‐13C]‐pyruvate. read more here.
Keywords: fourier based; model constrained; hyperpolarized 13c; constrained reconstruction ... See more keywords
Considerations for hyperpolarized 13C MR at reduced field: Comparing 1.5T versus 3T
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DOI: 10.1002/mrm.29579
Abstract: In contrast to conventional MR, signal‐to‐noise ratio (SNR) is not linearly dependent on field strength in hyperpolarized MR, as polarization is generated outside the MR system. Moreover, field inhomogeneity‐induced artifacts and other practical limitations associated… read more here.
Keywords: hyperpolarized 13c; considerations hyperpolarized; reduced field; field ... See more keywords
Assessment of focal renal ischemia–reperfusion injury in a porcine model using hyperpolarized [1‐13C]pyruvate MRI
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DOI: 10.1002/mrm.29649
Abstract: Ischemic injury in the kidney is a common pathophysiological event associated with both acute kidney injury and chronic kidney disease; however, regional ischemia–reperfusion as seen in thromboembolic renal disease is often undetectable and thus subclinical.… read more here.
Keywords: reperfusion injury; injury; ischemia reperfusion; hyperpolarized 13c ... See more keywords
An indirect method for in vivo T2 mapping of [1‐13C] pyruvate using hyperpolarized 13C CSI
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DOI: 10.1002/nbm.3690
Abstract: An indirect method for in vivo T2 mapping of 13C–labeled metabolites using T2 and T2* information of water protons obtained a priori is proposed. The T2 values of 13C metabolites are inferred using the relationship… read more here.
Keywords: 13c csi; vivo; method; indirect method ... See more keywords