Non-gestational choriocarcinoma with hyperprogression on pembrolizumab: A case report and review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2022.100923
Abstract: Highlights • Non gestational choriocarcinoma is diagnosed by history, pathology, & genetics.• There is a paucity of data regarding the efficacy of immunotherapy in this disease.• Hyperprogression on immunotherapy can occur in gynecologic malignancies.• Hyperprogression… read more here.
Keywords: hyperprogression pembrolizumab; choriocarcinoma hyperprogression; gestational choriocarcinoma; hyperprogression ... See more keywords
Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti–PD-1 immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq7019
Abstract: The tumor-intrinsic NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome–heat shock protein 70 (HSP70) signaling axis is triggered by CD8+ T cell cytotoxicity and contributes to the development of adaptive resistance to anti–programmed cell death… read more here.
Keywords: anti immunotherapy; hsp70 tlr4; hyperprogression; tumor ... See more keywords
Hyperprogression of cutaneous T cell lymphoma after anti–PD-1 treatment
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.164793
Abstract: BACKGROUND Immune checkpoint blockade is an emerging treatment for T cell non-Hodgkin’s lymphoma (T-NHL), but some patients with T-NHL have experienced hyperprogression with undetermined mechanisms upon anti–PD-1 therapy. METHODS Single-cell RNA-Seq, whole-genome sequencing, whole-exome sequencing,… read more here.
Keywords: cell; cell lymphoma; hyperprogression; treatment ... See more keywords
Hyperprogression and hypercalcemia after nivolumab treatment in three cases with renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552221077418
Abstract: Introduction Hyperprogression is a specific type of response seen with immunotherapy that is observed in all malignancies with a frequency of 9% - 29%, characterized by a rapid increase in tumor burden. Many possible related… read more here.
Keywords: hyperprogression; cell carcinoma; renal cell; hypercalcemia ... See more keywords
Hyperprogression in a Patient With Hepatocellular Cancer Treated With Atezolizumab and Bevacizumab: A Case Report and Review of Literature
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Investigative Medicine High Impact Case Reports"
DOI: 10.1177/2324709621992207
Abstract: Immune checkpoint inhibitors have emerged as a novel treatment in a wide variety of malignancies; however, it is associated with a distinctive array of side effects known as immune-related adverse events. Hyperprogression is defined as… read more here.
Keywords: hepatocellular cancer; atezolizumab bevacizumab; case; report ... See more keywords
PET/CT radiomics for prediction of hyperprogression in metastatic melanoma patients treated with immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.977822
Abstract: Purpose This study evaluated pretreatment 2[18F]fluoro-2-deoxy-D-glucose (FDG)-PET/CT-based radiomic signatures for prediction of hyperprogression in metastatic melanoma patients treated with immune checkpoint inhibition (ICI). Material and method Fifty-six consecutive metastatic melanoma patients treated with ICI and… read more here.
Keywords: pet; patients treated; melanoma patients; metastatic melanoma ... See more keywords