Hyperprogressive disease in patients with advanced renal cell carcinoma: a new pattern of post-treatment cancer behavior.
Sign Up to like & getrecommendations! Published in 2020 at "Immunologic research"
DOI: 10.1007/s12026-020-09138-4
Abstract: Renal cell carcinoma (RCC) is among the most common cancers of the genitourinary system. Once RCC has progressed to a high tumor stage, surgery is no longer the optimal option, and treatment with drugs is… read more here.
Keywords: renal cell; cell carcinoma; treatment; hyperprogressive disease ... See more keywords
Hyperprogressive disease after treatment with pembrolizumab in lung adenocarcinoma: An autopsy case study
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2019.100885
Abstract: Although immune-checkpoint inhibitors (ICIs) have become an important choice of treatment for advanced NSCLC, recent reports show hyperprogressive disease (HPD) after ICI administration. The clinico-pathological features of HPD still remain unclear. Here we report a… read more here.
Keywords: lung adenocarcinoma; hyperprogressive disease; treatment; disease ... See more keywords
Hyperprogressive disease in patients with non‐small cell lung cancer treated with nivolumab: A case series
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DOI: 10.1111/1759-7714.12894
Abstract: Nivolumab is an anti‐PD‐1 blocking monoclonal antibody approved for the treatment of non‐small cell lung cancer (NSCLC). However, some patients on immunotherapy may experience rapid progression and worsening clinical status, known as hyperprogressive disease. We… read more here.
Keywords: hyperprogressive disease; cell lung; non small; cancer ... See more keywords
Treg-Dominant Tumor Microenvironment Is Responsible for Hyperprogressive Disease after PD-1 Blockade Therapy
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DOI: 10.1158/2326-6066.cir-22-0041
Abstract: The mechanisms underlying hyperprogressive disease (HPD) associated with PD-1 blockade are unclear. The authors develop a way to reproduce HPD by partially eliminating CD8+ T cells with NIR-PIT, creating a regulatory T cell–dominant tumor microenvironment… read more here.
Keywords: dominant tumor; tumor microenvironment; tumor; hyperprogressive disease ... See more keywords
The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy
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DOI: 10.1186/s12943-020-01200-x
Abstract: Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies (Abs) and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) Abs, are effective for patients with various cancers. However, low response rates to ICI monotherapies and even hyperprogressive disease… read more here.
Keywords: hyperprogressive disease; disease; disease blockage; hpd ... See more keywords
Hyperprogressive disease in patients with recurrent high grade gliomas treated with immune checkpoint inhibitors or other therapies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e13575
Abstract: e13575 Background: Hyperprogressive disease (HPD) has been described in solid tumor patients treated with immune checkpoint inhibitors (ICI). HPD is defined as a ≥2-fold increase in tumor growth rate (TGR) following initiation of ICI. HPD… read more here.
Keywords: immune checkpoint; hyperprogressive disease; control group; hpd ... See more keywords
The ABCs of preventing hyperprogressive disease after immunotherapy: awareness, biomarkers, and combination.
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DOI: 10.21037/jtd.2018.12.112
Abstract: Hyperprogressive disease is a clinical term that describes the phenomenon of paradoxically accelerated tumor progression after initiation of treatment. Although there is no established definition for hyperprogressive disease, in clinical practice, we do experience patients… read more here.
Keywords: preventing hyperprogressive; disease immunotherapy; hyperprogressive disease; abcs preventing ... See more keywords
Hyperprogressive disease in hepatocellular carcinoma with immune checkpoint inhibitor use: a case series.
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DOI: 10.2217/imt-2018-0126
Abstract: Immune checkpoint inhibitors (ICIs) have demonstrated promising results in a variety of advanced cancer types. The phenomenon of hyperprogressive disease (HPD) has only been documented in recent years, however, there have been no reports of… read more here.
Keywords: hepatocellular carcinoma; immune checkpoint; carcinoma; hyperprogressive disease ... See more keywords
The Educational Program of Macrophages toward a Hyperprogressive Disease-Related Phenotype Is Orchestrated by Tumor-Derived Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415802
Abstract: Hyperprogressive disease (HPD), an aggressive acceleration of tumor growth, was observed in a group of cancer patients treated with anti-PD1/PDL1 antibodies. The presence of a peculiar macrophage subset in the tumor microenvironment is reported to… read more here.
Keywords: phenotype; related phenotype; hyperprogressive disease; derived extracellular ... See more keywords