The effect of sublingual atropine sulfate on clozapine-induced hypersalivation: a multicentre, randomised placebo-controlled trial.
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05627-4
Abstract: BACKGROUND Hypersalivation and drooling are commonly reported in clozapine-treated patients. Current management strategies have been evaluated using subjective measures. Many case reports describe the successful use of atropine in the treatment of the condition. AIMS… read more here.
Keywords: sublingual atropine; clozapine; hypersalivation; effect ... See more keywords
Hyoscine for clozapine-induced hypersalivation: a double-blind, randomized, placebo-controlled cross-over trial
Sign Up to like & getrecommendations! Published in 2019 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000251
Abstract: Clozapine is the only evidence-based antipsychotic for treatment-resistant schizophrenia. However, it has considerable side effects, limiting its usability and reducing patients’ adherence. One of the most common and distressing side effects is hypersalivation, which can… read more here.
Keywords: clozapine; placebo; induced hypersalivation; hypersalivation ... See more keywords
Glycopyrrolate in comparison to hyoscine hydrobromide and placebo in the treatment of hypersalivation induced by clozapine (GOTHIC1): a feasibility study
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DOI: 10.1186/s40814-019-0462-1
Abstract: BackgroundClozapine-induced hypersalivation (CIH) is a common side effect of clozapine treatment and is disliked by clozapine patients, potentially threatening adherence to clozapine treatment. We proposed a trial of alternative medications, hyoscine and glycopyrrolate, for the… read more here.
Keywords: feasibility study; hypersalivation; treatment; trial ... See more keywords
Efficacy of sofpironium bromide gel on clozapine-induced hypersalivation in patients with treatment-resistant schizophrenia: double-blind, controlled crossover study
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DOI: 10.1192/bjo.2022.630
Abstract: Background Hypersalivation is a major side-effect of clozapine in patients with treatment-resistant schizophrenia. Aims We investigated the efficacy of topical anticholinergic formulation sofpironium bromide gel for improving hypersalivation in patients with treatment-resistant schizophrenia receiving clozapine.… read more here.
Keywords: bromide gel; treatment; hypersalivation; sofpironium bromide ... See more keywords