The role of the XBP-1/AGR2 signaling pathway in the regulation of airway Mucin5ac hypersecretion under hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.05.023
Abstract: Oversecretion of Mucin5ac (MUC5AC), which is primarily synthesized by goblet cells and is the major gel-forming mucin, is a hallmark of various pulmonary inflammatory diseases. Hypoxia is considered a common pathophysiologic feature in various pulmonary… read more here.
Keywords: hif; agr2; muc5ac hypersecretion; hypersecretion ... See more keywords
Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion
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DOI: 10.1126/science.abd2893
Abstract: Sweat out the fat with TSLP! Thymic stromal lymphopoietin (TSLP) is a cytokine that can promote immune responses that characterize allergic diseases. Choa et al. found that mice engineered to produce elevated TSLP displayed selective… read more here.
Keywords: hypersecretion; sebum secretion; wat loss; tslp ... See more keywords
Targeting mucin hypersecretion in COVID-19 therapy
Sign Up to like & getrecommendations! Published in 2022 at "Future Medicinal Chemistry"
DOI: 10.4155/fmc-2021-0111
Abstract: “ The primary symptoms pertaining to the SARS-CoV-2-mediated cytokine storm involve hypersecretion of mucins, which potentially triggers various inflammatory pathways, contributing toward COVID-19 pathogenesis ” The primary symptoms pertaining to the SARS-CoV-2-mediated cytokine storm involve… read more here.
Keywords: hypersecretion; mucin hypersecretion; hypersecretion covid; targeting mucin ... See more keywords