Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4.
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DOI: 10.1007/s10753-025-02340-2
Abstract: Hypertension serves as a major contributing factor to various cardiovascular disorders, including heart failure. Ferroptosis-induced cardiomyocyte loss is recognized as a novel contributor to myocardial remodeling in heart failure. Membrane-associated RING-CH-type finger 6 (Marchf6) is… read more here.
Keywords: ferroptosis; cardiomyocyte ferroptosis; hypertension induced; hypertension ... See more keywords
Therapeutic potential of carbon monoxide in hypertension-induced vascular smooth muscle cell damage revisited: from physiology and pharmacology.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115008
Abstract: As a chronic and progressive disorder, hypertension remains to be a serious public health problem around the world. Among the different types of hypertension, pulmonary arterial hypertension (PAH) is a devastating disease associated with pulmonary… read more here.
Keywords: hypertension induced; carbon monoxide; physiology; vascular remodeling ... See more keywords
Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
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DOI: 10.1016/j.jphs.2018.05.008
Abstract: Mangiferin, a natural glucosyl xanthone, was confirmed to be an effective uric acid (UA)- lowering agent with dual action of inhibiting production and promoting excretion of UA. In this study, we aimed to evaluate the… read more here.
Keywords: nitric oxide; hyperuricemia via; induced hyperuricemia; hypertension induced ... See more keywords
Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses.
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DOI: 10.1016/j.lfs.2022.120424
Abstract: AIMS Hypertension is one of the major causes of cardiac damage. In this study, the effects of resveratrol supplementation and regular exercise on hypertension-induced cellular stress responses of myocardium were compared. MAIN METHODS Hypertension was… read more here.
Keywords: hypertension induced; stress; exercise; resveratrol regular ... See more keywords
Prevention of hypertension-induced vascular dementia by Lactobacillus paracasei subsp. paracasei NTU 101-fermented products
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DOI: 10.1080/13880209.2016.1253109
Abstract: Abstract Context: Numerous etiological studies have established positive clinical association between hypertension and vascular dementia (VaD). Lactobacillus paracasei subsp. paracasei NTU 101-fermented products have been shown to decrease vascular risk factors such as hypertension, atherosclerosis,… read more here.
Keywords: lactobacillus paracasei; paracasei subsp; hypertension induced; hypertension ... See more keywords
Lovastatin attenuates hypertension induced by renal tubule‐specific knockout of ATP‐binding cassette transporter A1, by inhibiting epithelial sodium channels
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DOI: 10.1111/bph.14775
Abstract: We have shown that cholesterol is synthesized in the principal cells of renal cortical collecting ducts (CCD) and stimulates the epithelial sodium channels (ENaC). Here we have determined whether lovastatin, a cholesterol synthesis inhibitor, can… read more here.
Keywords: hypertension induced; atp binding; binding cassette; epithelial sodium ... See more keywords
Metabolic rewiring of the hypertensive kidney
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DOI: 10.1126/scisignal.aax9760
Abstract: Multi-omics analyses reveal that metabolic changes occur early in hypertension-induced kidney disease. Metabolic changes under pressure Chronic hypertension causes irreversible damage to the kidneys. Rinschen et al. performed multi-omics analyses of kidney tissue from rats… read more here.
Keywords: metabolic changes; hypertension induced; disease; hypertension ... See more keywords
Effects of Finerenone Combined with Empagliflozin in a Model of Hypertension-Induced End-Organ Damage
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DOI: 10.1159/000516213
Abstract: Introduction: The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in CKD patients with type 2 diabetes. Clinical data analyzing the potential value of a combination therapy are… read more here.
Keywords: combination; low dose; dose combination; hypertension induced ... See more keywords
Abstract P141: Toll Like Receptor 4 Mediated Autophagy Contributes to Hypertension-Induced Kidney Injury
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DOI: 10.1161/hyp.74.suppl_1.p141
Abstract: Hypertension is the second leading cause of chronic kidney disease in the world. Angiotensin II (Ang II) induced Toll-like receptor 4, TLR4, activation contributes to hypertension-induced renal inflammation and fibrosis. Recently, we showed that mice… read more here.
Keywords: toll like; hypertension induced; like receptor; hypertension ... See more keywords
Global, regional, and national burden of hypertension-induced cardiorenal disease, 1990–2021 and projections to 2050: a systematic analysis for the global burden of disease study 2021
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DOI: 10.1186/s12889-025-23742-9
Abstract: To explore the impact of hypertension-induced cardiorenal disease on disability rates and mortality, this study reported the burden of cardiorenal disease caused by hypertension (including hypertensive heart disease [HHD] and hypertensive kidney disease) between 1990… read more here.
Keywords: disease; induced cardiorenal; cardiorenal disease; burden ... See more keywords
Pattern of sympathetic vasomotor activity in a model of hypertension induced by nitric oxide synthase blockade
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DOI: 10.14814/phy2.14183
Abstract: We aimed to investigate the effects of nitric oxide (NO) synthesis inhibition by NO synthase inhibitor N‐nitro‐L‐arginine‐methyl ester (L‐NAME) treatment on the sympathetic vasomotor nerve activity (SNA) on two sympathetic vasomotor nerves, the renal and… read more here.
Keywords: nitric oxide; sympathetic vasomotor; hypertension induced; synthase ... See more keywords