Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II‐infused hypertensive mice
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DOI: 10.1002/glia.23564
Abstract: Hypertension is an important contributor to cognitive decline but the underlying mechanisms are unknown. Although much focus has been placed on the effect of hypertension on vascular function, less is understood of its effects on… read more here.
Keywords: ca2 dynamics; tone; ca2; hypertension ... See more keywords
TRPV4 (Transient Receptor Potential Vanilloid 4) Mediates Endothelium-Dependent Contractions in the Aortas of Hypertensive Mice
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DOI: 10.1161/hypertensionaha.117.09767
Abstract: The role of TRPV4 (transient receptor potential vanilloid 4) in regulating vascular contraction in hypertensive mice is poorly established. We tested the hypothesis that TRPV4 regulates endothelium-dependent contractions in aortas from hypertensive mice through the… read more here.
Keywords: endothelium dependent; contractions aortas; trpv4; mice ... See more keywords
P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice
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DOI: 10.2991/artres.k.201209.068
Abstract: Methods: After AngII infusion (14-day, 1000 ng/kg/min) and euthanasia, excised thoracic aortas were characterized functionally using isobaric vasoactive and cyclic passive stiffness tests. Immunohistochemistry quantified medial/adventitial composition and infiltration of pan-inflammatory CD45+ cells. RNA sequencing-based… read more here.
Keywords: dictates aortic; background dictates; fibrosis hypertensive; genetic background ... See more keywords
Impact of Intratracheal Administration of Polyethylene Glycol-Coated Silver Nanoparticles on the Heart of Normotensive and Hypertensive Mice
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DOI: 10.3390/ijms24108890
Abstract: Silver nanoparticles are widely used in various industrial and biomedical applications; however, little is known about their potential cardiotoxicity after pulmonary exposure, particularly in hypertensive subjects. We assessed the cardiotoxicity of polyethylene glycol (PEG)-coated AgNPs… read more here.
Keywords: peg agnps; hypertensive mice; mice treated; heart ... See more keywords