Developmental characteristics of secondary cartilage in the mandibular condyle and sphenoid bone in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.12.027
Abstract: OBJECTIVE Secondary cartilage develops from osteochondral progenitor cells. Hypertrophic chondrocytes in secondary cartilage increase within a very short time and then ossify rapidly. In the present study, we investigated the sequential development process of osteochondral… read more here.
Keywords: mandibular condyle; hypertrophic chondrocytes; sphenoid bone; secondary cartilage ... See more keywords
FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes: Association with chondrocyte death in deep zone of Kashin-Beck disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.023
Abstract: OBJECTIVE The aim of this study was to investigate FGF8 and FGFR3 expression in clinical samples of Kashin-Beck disease (KBD), an endemic osteochondropathy found in China, as well as in pre-clinical models of this disease.… read more here.
Keywords: hypertrophic chondrocytes; fgf8 fgfr3; deep zone; fgfr3 ... See more keywords
Heparan Sulfate Deficiency Leads to Hypertrophic Chondrocytes by Increasing Bone Morphogenetic Protein Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.08.003
Abstract: OBJECTIVE Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis. Previous studies investigating HS in several mouse models of multiple hereditary exostoses have… read more here.
Keywords: hypertrophic chondrocytes; cko mice; mice; ext1 cko ... See more keywords
4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.149636
Abstract: Short stature is a major skeletal phenotype in osteogenesis imperfecta (OI), a genetic disorder mainly caused by mutations in genes encoding type I collagen. However, the underlying mechanism is poorly understood, and no effective treatment… read more here.
Keywords: growth; growth deficiency; hypertrophic chondrocytes; osteogenesis imperfecta ... See more keywords
Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009169
Abstract: Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts. Runx2 is essential for osteoblast… read more here.
Keywords: transdifferentiation; vascular invasion; hypertrophic chondrocytes; invasion cartilage ... See more keywords
Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042084
Abstract: Osteoarthritis (OA) is a whole joint disease characterized by an important remodeling of the osteochondral junction. It includes cartilage mineralization due to chondrocyte hypertrophic differentiation and bone sclerosis. Here, we investigated whether gremlin-1 (Grem-1) and… read more here.
Keywords: osteochondral junction; bmp; hypertrophic chondrocytes; grem bmp ... See more keywords