Early Addition of Parathyroid Hormone-Related Peptide Regulates the Hypertrophic Differentiation of Mesenchymal Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cartilage"
DOI: 10.1177/1947603519894727
Abstract: OBJECTIVE Chondrogenic differentiation of mesenchymal stem cells (MSCs) into hyaline cartilage is complicated by terminal hypertrophic differentiation. In growth plate, parathyroid hormone-related peptide (1-34) (PTHrP) plays a crucial role in maintaining chondrocytes in their proliferation… read more here.
Keywords: differentiation mesenchymal; hypertrophic differentiation; differentiation; chondrogenic differentiation ... See more keywords
PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation
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DOI: 10.1371/journal.pone.0213483
Abstract: Regenerated cartilage formed after Autologous Chondrocyte Implantation may be of suboptimal quality due to postulated hypertrophic changes. Parathyroid hormone-related peptide, containing the parathyroid hormone sequence (PTHrP 1–34), enhances cartilage growth during development and inhibits hypertrophic… read more here.
Keywords: pth; type collagen; hypertrophic differentiation; cartilage ... See more keywords
RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes
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DOI: 10.7150/ijbs.74895
Abstract: Background: Chondrocyte hypertrophy has been implicated in endochondral ossification and osteoarthritis (OA). In OA, hypertrophic chondrocytes contribute to the destruction and focal calcification of the joint cartilage. Although studies in this field have remarkably developed… read more here.
Keywords: long non; chondrocyte; hypertrophic changes; hypertrophic differentiation ... See more keywords