Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.100
Abstract: Pathological cardiac hypertrophy is the main risk factor for heart diseases. The ubiquitin-proteasome system (UPS) is the major intracellular protein degradation system involved in the development of cardiac hypertrophic remodeling. Ubiquitin-activating enzyme E1, a key… read more here.
Keywords: pyr; hypertrophic remodeling; inhibitor pyr; uba1 inhibitor ... See more keywords
[PP.19.15] RETINAL ARTERIOLES HYPERTROPHIC REMODELING IN UNCONTROLLED ACROMEGALY
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523706.72591.49
Abstract: Objective: Acromegaly is characterized by an increased cardiovascular risk. Hypertrophic effects of Growth Hormone (GH)/Insulin-like Growth Factor 1 (IGF1) system on the heart and large arteries are known but little data on microcirculation exist. Our… read more here.
Keywords: hypertrophic remodeling; controlled acromegaly; uncontrolled acromegaly; optics ... See more keywords