β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2614
Abstract: Hypertrophic scar (HS) is a condition characterized by excessive synthesis and deposition of collagen. There are many clinical methods to alleviate HS, but most of them are accompanied by many complications. To investigate the effects… read more here.
Keywords: hypertrophic scar; scar; p53; induces apoptosis ... See more keywords
Adipose tissue‐derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27689
Abstract: The current study was designed to investigate the effects and underlying mechanisms of adipose tissue‐derived stem cells (ADSCs) on hypertrophic scar (HS) fibrosis. read more here.
Keywords: hypertrophic scar; derived stem; scar fibrosis; adipose tissue ... See more keywords
Laser-assisted drug delivery of synthetic alpha melanocyte stimulating hormone and L-tyrosine leads to increased pigmentation area and expression of melanogenesis genes in a porcine hypertrophic scar model.
Sign Up to like & getrecommendations! Published in 2023 at "Lasers in surgery and medicine"
DOI: 10.1002/lsm.23663
Abstract: One symptom of hypertrophic scar (HTS) that can develop after burn injury is dyschromia with hyper‐ and hypopigmentation. There are limited treatments for these conditions. Previously, we showed there is no expression of alpha melanocyte… read more here.
Keywords: assisted drug; hypertrophic scar; alpha melanocyte; stimulating hormone ... See more keywords
Effect of artesunate and relation with TGF-β1 and SMAD3 signaling on experimental hypertrophic scar model in rabbit ear
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-019-01960-7
Abstract: Artesunate (ART) is the derivative of artemisinin isolated from the traditional Chinese medicine qinghao. Although several studies reported the efficiency of artesunate in the treatment of malaria, inhibiting fibroblasts and collagen synthesis, the association between… read more here.
Keywords: hypertrophic scar; rabbit ear; group; artesunate ... See more keywords
Exosomes derived from human hypertrophic scar fibroblasts induces smad and TAK1 signaling in normal dermal fibroblasts.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109215
Abstract: Post-burn hypertrophic scars are characterized by excessive accumulation of extracellular matrix secreted by fibroblasts. Exosomes are membrane lipid extracellular vesicles that play a pivotal role in cellular communication. Previous studies revealed the role of stem… read more here.
Keywords: scar fibroblasts; htsfs derived; hypertrophic scar; exosomes derived ... See more keywords
Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.161
Abstract: It is of great clinical significance to design wound dressing materials with combined excellent wound healing properties and superior capability to suppress hypertrophic scar formation. This study aimed to examine if and how the cationicity… read more here.
Keywords: wound healing; hypertrophic scar; chitosan; scar formation ... See more keywords
Emerging evidence for the roles of peptide in hypertrophic scar.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117174
Abstract: Hypertrophic scar is a dermal fibroproliferative disorder characterized by excess collagen deposition. There are many existing treatment modalities, but none works perfectly in all individuals. Recently, evidence is increasing that peptides can play crucial roles… read more here.
Keywords: hypertrophic scar; roles peptide; emerging evidence; scar ... See more keywords
Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1959221
Abstract: Long non-coding RNAs (lncRNAs) play crucial roles in human diseases. However, the detailed role of lncRNAs in hypertrophic scar fibroblasts (HSFs) is inadequately understood. This study aimed to investigate the potential role of lncRNA nuclear… read more here.
Keywords: hypertrophic scar; mir; long non; non coding ... See more keywords
Hypertrophic Scar After Treatment of Ecchymoses With Pulsed-Dye Laser.
Sign Up to like & getrecommendations! Published in 2019 at "Dermatologic Surgery"
DOI: 10.1097/dss.0000000000001907
Abstract: Thepulsed-dye laser (PDL) has beenwidely used for the treatment of cutaneous vascular lesions. Although treatmentwithPDLhas beendemonstrated tobe safe in general, it can cause complications including scars, blisters, dyspigmentation, or dermatitis. Recently, PDL has been increasingly… read more here.
Keywords: treatment; ecchymoses pulsed; hypertrophic scar; scar treatment ... See more keywords
Prognostic tools for hypertrophic scar formation based on fundamental differences in systemic immunity
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Dermatology"
DOI: 10.1111/exd.14139
Abstract: Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed.… read more here.
Keywords: formation based; hypertrophic scar; prognostic tools; tools hypertrophic ... See more keywords
TSG‐6 inhibits hypertrophic scar fibroblast proliferation by regulating IRE1α/TRAF2/NF‐κB signalling
Sign Up to like & getrecommendations! Published in 2022 at "International Wound Journal"
DOI: 10.1111/iwj.13950
Abstract: TNF‐stimulated gene (TSG‐6) was reported to suppress hypertrophic scar (HS) formation in a rabbit ear model, and the overexpression of TSG‐6 in human HS fibroblasts (HSFs) was found to induce their apoptotic death. The molecular… read more here.
Keywords: traf2 signalling; hypertrophic scar; tsg; proliferation ... See more keywords