Propolis compound inhibits profibrotic TGF-β1/SMAD signalling in human fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07918-2
Abstract: Hypertrophic scarring of the skin is a cause of pain, disfigurement, and restricted mobility. Excessive TGF-β1 signalling leads to SMAD3 phosphorylation, which is implicated in hypertrophic scarring. In this study, we examined the mechanism of… read more here.
Keywords: smad signalling; hypertrophic scarring; tgf; expression ... See more keywords
Efficacy and possible mechanisms of Botulinum Toxin type A on hypertrophic scarring
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.12534
Abstract: Clinical observations indicate that Botulinum toxin type A (BTXA) can inhibit the growth and improve the eventual appearance of hypertrophic scarring. However, the molecular mechanism remains unclear. read more here.
Keywords: hypertrophic scarring; toxin type; botulinum toxin;
Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.823694
Abstract: Hypertrophic scars or keloid form as part of the wound healing reaction process, and its formation mechanism is complex and diverse, involving multi-stage synergistic action of multiple cells and factors. Adipose stem cells (ASCs) have… read more here.
Keywords: scarring keloid; stem cells; adipose stem; hypertrophic scarring ... See more keywords
Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1028410
Abstract: Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent studies indicate that mechanical force significantly impacts wound healing and skin regeneration which opens up a new direction to combat scarring. Hence,… read more here.
Keywords: wound healing; hypertrophic scarring; scar; scar formation ... See more keywords
Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2024.1345717
Abstract: Hypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can… read more here.
Keywords: hypertrophic scarring; gut microbiota; microbiota hypertrophic; bidirectional mendelian ... See more keywords
MicroRNA-365a/b-3p as a Potential Biomarker for Hypertrophic Scars
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116117
Abstract: The clinical aspects of hypertrophic scarring vary according to personal constitution and body part. However, the mechanism of hypertrophic scar (HS) formation remains unclear. MicroRNAs (miRNAs) are known to contribute to HS formation, however, their… read more here.
Keywords: hypertrophic scarring; mir 365a; microrna 365a; potential biomarker ... See more keywords