Protective effect of histone methyltransferase NSD3 on ISO‐induced cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13515
Abstract: Nuclear receptor‐binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential roles in the cardiovascular system remain unknown. In this study, we found that NSD3… read more here.
Keywords: cardiomyocyte hypertrophy; protective effect; methyltransferase; hypertrophy ... See more keywords
Genome‐wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14168
Abstract: LIM‐domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome‐wide level, which are crucial to further understand their functions in cardiac hypertrophy, are… read more here.
Keywords: genome wide; cardiac hypertrophy; analysis mouse; family ... See more keywords
HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300585
Abstract: Inhibition of pathological cardiac hypertrophy is recognized as an important therapeutic strategy for heart failure, although effective targets are still lacking in clinical practice. Homeodomain interacting protein kinase 1 (HIPK1) is a conserved serine/threonine kinase… read more here.
Keywords: pathological cardiac; hypertrophy; hipk1; cardiac hypertrophy ... See more keywords
SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy
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DOI: 10.1002/advs.202305677
Abstract: Pathological cardiac hypertrophy is the leading cause of heart failure and has an extremely complicated pathogenesis. TEA domain transcription factor 1 (TEAD1) is recognized as an important transcription factor that plays a key regulatory role… read more here.
Keywords: cardiac hypertrophy; hypertrophy; pathological cardiac; sumoylation tead1 ... See more keywords
The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4
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DOI: 10.1002/advs.202308769
Abstract: Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1‐catalyzed RNA N7‐methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate… read more here.
Keywords: cardiac hypertrophy; hypertrophy; m7g methyltransferase; srsf9 ... See more keywords
LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507365
Abstract: Heart failure (HF) as the terminal stage of various cardiac diseases, its underlying molecular mechanisms still remain elusive. Emerging evidence have implicated long noncoding RNAs (lncRNAs) play a multifaceted role in the progression of cardiac… read more here.
Keywords: cardiac hypertrophy; hypertrophy; foxo6os novel; heart failure ... See more keywords
Synergistic effects of biological stimuli and flexion induce microcavities promote hypertrophy and inhibit chondrogenesis during in vitro culture of human mesenchymal stem cell aggregates
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400060
Abstract: Interzone/cavitation are key steps in early stage joint formation that have not been successfully developed in vitro. Further, current models of endochondral ossification, an important step in early bone formation, lack key morphology morphological structures… read more here.
Keywords: hypertrophy; early stage; chondrogenesis; culture ... See more keywords
Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway
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DOI: 10.1002/cbin.11146
Abstract: Cardiac hypertrophy is a common pathological change found in various cardiovascular diseases. Although it has long been recognized as an important risk factor responsible for heart failure, there is still a lack of effective treatments… read more here.
Keywords: cardiac hypertrophy; transcription; induced cardiac; hypertrophy ... See more keywords
Inhibition of intermittent calcium‐activated potassium channel (SK4) attenuates Ang II‐induced hypertrophy of human‐induced stem cell‐derived cardiomyocytes via targeting Ras–Raf–MEK1/2–ERK1/2 and CN–NFAT signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11948
Abstract: Cardiac hypertrophy caused by angiotensin II (Ang II) is essential for the pathological process of heart failure. The intermediate calcium‐activated potassium channel (SK4) has been shown to be involved in the process of the inflammatory… read more here.
Keywords: cell; hypertrophy; cardiac hypertrophy; calcium activated ... See more keywords
Electrocardiographic criteria which have the best prognostic significance in hypertensive patients with echocardiographic hypertrophy of left ventricle: 15‐year prospective study
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DOI: 10.1002/clc.23402
Abstract: Electrocardiography is the first‐choice technique for detecting left ventricular hypertrophy in patients with arterial hypertension. It is necessary to know the probable outcome for every patient during the treatment, with the aim of improving cardiovascular… read more here.
Keywords: significance hypertensive; criteria best; hypertrophy; best prognostic ... See more keywords
Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor‐dependent activation of β‐catenin in 5/6 nephrectomy rats
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DOI: 10.1002/ehf2.13269
Abstract: Prostaglandin E2 (PGE2) is involved in the development of cardiac hypertrophy. However, whether PGE2 regulates the chronic kidney disease‐associated cardiac hypertrophy and the tentative mechanism remains to be elucidated. read more here.
Keywords: cardiac hypertrophy; induced cardiac; hypertrophy ep2; hypertrophy ... See more keywords