Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112050
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Si-Miao-Yong-An decoction (SMYAD) is a traditional Chinese herbal formulation. SMYAD first appeared in the Eastern Han Dynasty according to the "Shen Yi Mi Zhuan". Then the formula was recorded in the "Yan Fang… read more here.
Keywords: cardiac hypertrophy; hypertrophy fibrosis; isoprenaline; heart failure ... See more keywords
Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Nutrition"
DOI: 10.1017/s0007114522000472
Abstract: Abstract Cardiac hypertrophy is the enlargement of cardiomyocytes in response to persistent release of catecholamine which further leads to cardiac fibrosis. Chrysin, flavonoid from honey, is well known for its multifarious properties like antioxidant, anti-inflammatory,… read more here.
Keywords: hypertrophy; cardiac hypertrophy; chrysin; iso ... See more keywords
Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure
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DOI: 10.1038/s41598-019-41491-9
Abstract: Heart failure (HF) is the leading cause of death in the Western world. Pathophysiological processes underlying HF development, including cardiac hypertrophy, fibrosis and inflammation, are controlled by specific microRNAs (miRNAs). Whereas most studies investigate miRNA… read more here.
Keywords: multi cellular; hypertrophy fibrosis; cellular regulators; heart failure ... See more keywords
Loss of Ten-Eleven Translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.
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DOI: 10.1093/hmg/ddab046
Abstract: The ten-eleven translocation (Tet) family of dioxygenases convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Previous studies have shown that 5hmC-mediated epigenetic modifications play essential roles in diverse biological processes and diseases. Here we show that Tet proteins… read more here.
Keywords: cardiac hypertrophy; ten eleven; hypertrophy; erk signaling ... See more keywords
Hypertrophy and Fibrosis of the Ligamentum Flavum in Lumbar Spinal Stenosis is Associated With Increased Expression of LPA and LPAR1
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DOI: 10.1097/bsd.0000000000000048
Abstract: Study Design: Histologic, immunohistochemical (IHC), and enzyme-linked immunosorbent assay analysis of the human ligamentum flavum (LF). Objective: The purpose of this study was to determine the level of expression of lysophosphatidic acid (LPA) in the… read more here.
Keywords: hypertrophy fibrosis; lpar1; expression; lpa ... See more keywords
Syringic acid mitigates isoproterenol‐induced cardiac hypertrophy and fibrosis by downregulating Ereg
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DOI: 10.1111/jcmm.17449
Abstract: Gallic acid has been reported to mitigate cardiac hypertrophy, fibrosis and arterial hypertension. The effects of syringic acid, a derivative of gallic acid, on cardiac hypertrophy and fibrosis have not been previously investigated. This study… read more here.
Keywords: isoproterenol induced; cardiac hypertrophy; syringic acid; fibrosis ... See more keywords
Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension
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DOI: 10.1186/s12967-017-1299-0
Abstract: BackgroundMeaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.MethodsFor induction of heart failure, cardiac hypertrophy and fibrosis, a bare metal… read more here.
Keywords: cardiac hypertrophy; fibrosis; porcine model; hypertrophy ... See more keywords
Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats.
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DOI: 10.5603/cj.a2018.0048
Abstract: BACKGROUND Recent clinical studies have shown that treatment with LCZ696, a complex containing the angiotensin receptor blocker valsartan and neprilysin inhibitor sacubitril, improves the prognosis of heart failure patients with a reduced ejection fraction. This… read more here.
Keywords: fibrosis; iso; angiotensin receptor; neprilysin inhibitor ... See more keywords