Mesenchymal stem cells transplantation attenuates hyperuricemic nephropathy in rats.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108000
Abstract: Mesenchymal stem cells (MSCs), due to their multi-directional differentiation, paracrine and immunomodulation potentials, and the capacity of homing to target organ, have been reported to facilitate regeneration and repair of kidney and improve kidney function… read more here.
Keywords: hyperuricemic nephropathy; mesenchymal stem; mscs treatment; stem cells ... See more keywords
Integration of network pharmacology and intestinal flora to investigate the mechanism of action of Chinese herbal Cichorium intybus formula in attenuating adenine and ethambutol hydrochloride-induced hyperuricemic nephropathy in rats
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2147551
Abstract: Abstract Context Cichorium intybus L. (Asteraceae) formula (CF) has been applied as a folk medicine to treat hyperuricemic nephropathy (HN). However, the exact mechanism remains unclear. Objective To explore the therapeutic effect and mechanism of… read more here.
Keywords: network; cichorium intybus; pharmacology; ethambutol hydrochloride ... See more keywords
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF‐κB signalling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Nephrology"
DOI: 10.1111/nep.14159
Abstract: Inflammation and apoptosis are main pathological processes that lead to the development of hyperuricemic nephropathy (HN). This study aims to explore whether baicalin (BA) and baicalein (BAI) can relieve the damage through PI3K/AKT/NF‐κB signal pathway… read more here.
Keywords: pi3k akt; baicalin baicalein; attenuate hyperuricemic; hyperuricemic nephropathy ... See more keywords
Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4085196
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Excessive serum uric acid (SUA) causes hyperuricemic nephropathy (HN), characterized by inflammatory infiltration and tubulointerstitial fibrosis. Most recently, we demonstrated that Fufang Zhenzhu Tiaozhi (FTZ) capsule attenuated diabetic nephropathy through inhibition of renal… read more here.
Keywords: pi3k akt; fufang zhenzhu; hyperuricemic nephropathy; akt pathway ... See more keywords
Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s247091
Abstract: Purpose Hyperuricemia is an independent risk factor for renal damage and can promote the progression of chronic kidney disease (CKD). In the present study, we employ a rat model to investigate the effects of rosiglitazone… read more here.
Keywords: treatment; hyperuricemic nephropathy; rat model; agonist ... See more keywords
Blockade of Autophagy Prevents the Progression of Hyperuricemic Nephropathy Through Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.858494
Abstract: Hyperuricemia has become a common metabolic disease, and is a risk factor for multiple diseases, including chronic kidney disease. Our recent study indicated that following persistent uric acid stimulation, autophagy was activated in rats of… read more here.
Keywords: nlrp3 inflammasome; activation; pyroptosis; hyperuricemic nephropathy ... See more keywords