Targeted degradation of ABCG2 for reversing multidrug resistance by hypervalent bispecific gold nanoparticle-anchored aptamer chimeras.
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DOI: 10.1039/d3cc00168g
Abstract: Hypervalent bispecific gold nanoparticle-anchored aptamer chimeras (AuNP-APTACs) were designed as a new tool of lysosome-targeting chimeras (LYTACs) for efficient degradation of the ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) to reverse multidrug resistance (MDR)… read more here.
Keywords: anchored aptamer; gold nanoparticle; hypervalent bispecific; bispecific gold ... See more keywords