The mechanism study of YZG-331 on sedative and hypnotic effects
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2022.113885
Abstract: YZG-331 is a synthetic novel derivates of N6-(4-hydroxybenzyl) adenine riboside (NHBA), which has potent sedative and hypnotic effects based on our previous study. We are now aiming to investigate the mechanism of YZG-331. In this… read more here.
Keywords: sedative hypnotic; study; yzg 331; mechanism ... See more keywords
Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113627
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Traditional Chinese medicine believes that depression syndrome has become one of the core pathogenesis of insomnia. The pharmacology of traditional Chinese medicine points out that Perilla frutescens has the effect of regulating Qi… read more here.
Keywords: medicine; sedative hypnotic; effects perilla; hypnotic effects ... See more keywords
Scn4b regulates the hypnotic effects of ethanol and other sedative drugs
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1111/gbb.12562
Abstract: The voltage‐gated sodium channel subunit β4 (SCN4B) regulates neuronal activity by modulating channel gating and has been implicated in ethanol consumption in rodent models and human alcoholics. However, the functional role for Scn4b in ethanol‐mediated… read more here.
Keywords: scn4b mice; scn4b regulates; hypnotic effects; effects ethanol ... See more keywords
Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/6198067
Abstract: Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative… read more here.
Keywords: sedative hypnotic; pinelliae rhizoma; hypnotic effects; rhizoma praeparatum ... See more keywords
Comparative Study on Sedative and Hypnotic Effects of Crude and Parched Semen Ziziphi Spinosae: Integration of Network Pharmacology and In Vivo Pharmacological Evaluation.
Sign Up to like & getrecommendations! Published in 2025 at "Current computer-aided drug design"
DOI: 10.2174/0115734099281920240730051328
Abstract: OBJECTIVE This study aimed to investigate the medicinal properties of SZS before and after processing and provide novel insights into its potential for treating insomnia. METHODS This study employed the network pharmacology platform to gather… read more here.
Keywords: sedative hypnotic; hypnotic effects; network pharmacology; pharmacology ... See more keywords
Pharmacological Analysis of GABAA Receptor and Sigma1R Chaperone Interaction: Research Report I―Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABAA Receptors’ Ligands
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119580
Abstract: Two groups of facts have been established in previous drug development studies of the non-benzodiazepine anxiolytic fabomotizole. First, fabomotizole prevents stress-induced decrease in binding ability of the GABAA receptor’s benzodiazepine site. Second, fabomotizole is a… read more here.
Keywords: sigma1r chaperone; hypnotic effects; gabaa; gabaa receptor ... See more keywords
Marine Polyphenol Phlorotannins as a Natural Sleep Aid for Treatment of Insomnia: A Review of Sedative–Hypnotic Effects and Mechanism of Action
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20120774
Abstract: Insomnia is a common sleep disorder. Natural sleep aids are gaining worldwide popularity as alternatives to prescription drugs for improving sleep. Recently, numerous studies have investigated the sedative–hypnotic effects of the polyphenols of terrestrial plants.… read more here.
Keywords: phlorotannins natural; hypnotic effects; review; natural sleep ... See more keywords
Sedum kamtschaticum Exerts Hypnotic Effects via the Adenosine A2A Receptor in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Nutrients"
DOI: 10.3390/nu16162611
Abstract: Insomnia is a common sleep disorder with significant societal and economic impacts. Current pharmacotherapies for insomnia are often accompanied by side effects, necessitating the development of new therapeutic drugs. In this study, the hypnotic effects… read more here.
Keywords: receptor; adenosine a2a; hypnotic effects; esk myricitrin ... See more keywords