Associations between spontaneous electroencephalogram oscillations and oxygen saturation across normobaric and hypobaric hypoxia
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26214
Abstract: High‐altitude indoctrination (HAI) trains individuals to recognize symptoms of hypoxia by simulating high‐altitude conditions using normobaric (NH) or hypobaric (HH) hypoxia. Previous studies suggest that despite equivalent inspired oxygen levels, physiological differences could exist between… read more here.
Keywords: hypobaric hypoxia; oxygen saturation; spo2 correlations; normobaric hypobaric ... See more keywords
Hypobaric hypoxia regulates iron metabolism in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28683
Abstract: Intermittent hypobaric hypoxia can produce a protective effect on both the nervous system and non‐nervous system tissues. Intermittent hypobaric hypoxia preconditioning has been shown to protect rats from cardiac ischemia‐reperfusion injury by decreasing cardiac iron… read more here.
Keywords: hypobaric hypoxia; treatment; hypoxia; iron metabolism ... See more keywords
Hypobaric Hypoxia Induces Deficits in Adult Neurogenesis and Social Interaction via Cyclooxygenase-1/ EP1 Receptor Pathway Activating NLRP3 Inflammasome.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02750-5
Abstract: Low oxygen environments, like hypobaric hypoxia (HH), are common nodes in a number of diseases characterized by neuroinflammation, which is detrimental to the structural and functional aspects of hippocampal circuitry. Hypoxic conditions lead to elevation… read more here.
Keywords: ep1 receptor; adult neurogenesis; neurogenesis social; hypobaric hypoxia ... See more keywords
Adenosine A2A receptor involves in neuroinflammation-mediated cognitive decline through activating microglia under acute hypobaric hypoxia
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.02.038
Abstract: HighlightsAcute HH induced cognitive impairments and neuroinflammation in the hippocampus.Genetic A2AR deletion attenuated acute HH‐induced impairment of spatial memory.Hippocampal A2ARs were mainly expressed on microglia and up‐regulated in acute HH model of mice.Microglia‐mediated neuroinflammation by… read more here.
Keywords: a2ar; spatial memory; adenosine a2a; hypobaric hypoxia ... See more keywords
A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116258
Abstract: Mountaineering and exposure to high altitude result in physiological adaptations to the reduced inspiratory oxygen availability. Acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE) are well-described harmful effects… read more here.
Keywords: hypobaric hypoxia; skeletal effects; exposure high; altitude ... See more keywords
Preventive preclinical efficacy of intravenously administered sphingosine-1-phosphate (S1P) in strengthening hypoxia adaptive responses to acute and sub-chronic hypobaric hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172877
Abstract: Sphingosine-1-phosphate (S1P) is emerging as a hypoxia responsive bio-lipid; systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning effects. The study aims to evaluate the hypoxia pre-conditioning efficacy of exogenously administered S1P… read more here.
Keywords: sub chronic; hypobaric hypoxia; s1p; hypoxia ... See more keywords
Expression of Hypoxia-Inducible Factor-1α and Myoglobin in Rat Heart as Adaptive Response to Intermittent Hypobaric Hypoxia Exposure
Sign Up to like & getrecommendations! Published in 2017 at "Hayati Journal of Biosciences"
DOI: 10.1016/j.hjb.2017.08.010
Abstract: Abstract The aim of this study was to investigate the influence of intermittent hypobaric hypoxia on the expression hypoxia adaptation proteins, namely hypoxia inducibla factor-1a (HIF-1a) and myoglobin (Mb). Twenty five male Sprague-Dawley rats were… read more here.
Keywords: hypoxia; intermittent hypobaric; expression; hypobaric hypoxia ... See more keywords
Protective effects of two novel nitronyl nitroxide radicals on heart failure induced by hypobaric hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.05.037
Abstract: AIMS Hypobaric hypoxia (HH), linked to oxidative stress, impairs cardiac function. We synthesized a novel nitronyl nitroxide radical, an HPN derivative (HEPN) and investigated the protective effects of HEPN and HPN against HH-induced heart injury… read more here.
Keywords: nitronyl nitroxide; novel nitronyl; hepn; heart ... See more keywords
Fear memory is impaired in hypobaric hypoxia: Role of synaptic plasticity and neuro-modulators in limbic region.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117555
Abstract: AIMS Evidences suggest that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting to associated cognitive dysfunction. However, possible effect of HH on amygdala and the associated limbic regions (prefrontal cortex… read more here.
Keywords: limbic region; hypobaric hypoxia; fear memory; synaptic plasticity ... See more keywords
Controlled hypobaric hypoxia increases immunological tolerance by modifying HLA-G expression, a potential therapy to inflammatory diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.109664
Abstract: One of the most striking characteristics of human beings is the incredible capacity to adapt to different environments. This capacity allowed humans to spread all over our planet, occupying habitats as diverse as deserts, tropical… read more here.
Keywords: therapy; hypobaric hypoxia; controlled hypobaric; hypoxia ... See more keywords
Transcription Factors Regulation in Human Peripheral White Blood Cells during Hypobaric Hypoxia Exposure: an in-vivo experimental study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46391-6
Abstract: High altitude is a natural laboratory, within which the clinical study of human physiological response to hypobaric hypoxia (HH) is possible. Failure in the response results in progressive hypoxemia, inflammation and increased tissue oxidative stress… read more here.
Keywords: hypobaric hypoxia; mrna levels; exposure; study ... See more keywords