Sleep: Short Sleepers Should Keep Count of Their Hypocretin Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.03.006
Abstract: Sleep durations vary greatly across animals from 2 to 20 hours with no clear explanation. A small Mexican cavefish reveals how the brain can adapt to increase its wake-stabilizing hypocretin circuit and dramatically reduce sleep,… read more here.
Keywords: short sleepers; count hypocretin; sleepers keep; sleep short ... See more keywords
Utility of measuring CSF hypocretin-1 level in patients with suspected narcolepsy.
Sign Up to like & getrecommendations! Published in 2020 at "Sleep medicine"
DOI: 10.1016/j.sleep.2020.03.009
Abstract: OBJECTIVES The patho-aetiology of narcolepsy Type I (NT1) is the loss of hypocretin-1 secreting neurons in the hypothalamus. Diagnostic criteria for NT1 include excessive daytime sleepiness (EDS) for at least three months not explained by… read more here.
Keywords: measuring csf; patients suspected; suspected narcolepsy; csf hypocretin ... See more keywords
Intermediate hypocretin-1 cerebrospinal fluid levels and typical cataplexy: their significance in the diagnosis of narcolepsy type 1
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac052
Abstract: Abstract Study Objectives The diagnosis of narcolepsy type 1 (NT1) is based upon the presence of cataplexy and/or a cerebrospinal fluid (CSF) hypocretin-1/orexin-A level ≤ 110 pg/mL. We determined the clinical and diagnostic characteristics of patients with… read more here.
Keywords: hypocretin; hypocretin levels; intermediate hypocretin; typical cataplexy ... See more keywords
Hypocretin-1 measurements in cerebrospinal fluid using radioimmunoassay: within and between assay reliability and limit of quantification
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac103
Abstract: Abstract Study Objectives The most sensitive and specific investigative method for the diagnosis of narcolepsy type 1 (NT1) is the determination of hypocretin-1 (orexin-A) deficiency (≤110 pg/mL) in cerebrospinal fluid using a radioimmunoassay (RIA). We… read more here.
Keywords: limit quantification; hypocretin; fluid using; reliability ... See more keywords
Eat, seek, rest? An orexin/hypocretin perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuroendocrinology"
DOI: 10.1111/jne.13259
Abstract: Seeking and ingesting nutrients is an essential cycle of life in all species. In classical neuropsychology these two behaviours are viewed as fundamentally distinct from each other, and known as appetitive and consummatory, respectively. Appetitive… read more here.
Keywords: hypocretin; orexin; eat; rest ... See more keywords
In Vitro Treg Immunosuppression Assay of GITR Proteins Could Elucidate the Autoimmune-mediated Mechanism Underlying Type 1 Narcolepsy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurosurgery"
DOI: 10.33137/jns.v2i1.34611
Abstract: Abstract: Type 1 narcolepsy is a hypersomnia sleep disorder characterized by excessive daytime sleep and shallow NREM nighttime sleep. Deficiency of hypocretin-1 secreting neurons in the lateral hypothalamus is the primary cause of the disorder… read more here.
Keywords: type narcolepsy; gitr; mediated mechanism; narcolepsy ... See more keywords
Narcolepsy and H1N1 influenza immunology a decade later: What have we learned?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.902840
Abstract: In the wake of the A/California/7/2009 H1N1 influenza pandemic vaccination campaigns in 2009-2010, an increased incidence of the chronic sleep-wake disorder narcolepsy was detected in children and adolescents in several European countries. Over the last… read more here.
Keywords: h1n1; hypocretin; h1n1 influenza; risk ... See more keywords
Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2021.676336
Abstract: As hypocretin can markedly affect neurophysiological and behavioural processes in mood disorders. However, few studies have measured changes in hypocretin levels in patients with mood disorders. We estimated the hypocretin-1 plasma levels in mood disorder… read more here.
Keywords: plasma; mdd; hypocretin; disorder patients ... See more keywords