Sleep/wake disorders and the hypocretin/orexin system in a zebrafish model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.352
Abstract: ICM P09-015-F FONDECYT 3150540 1161274 1151029 CONICYT PIA ACT1402 FONDAP 15150012 read more here.
Keywords: sleep wake; hypocretin orexin; system zebrafish; disorders hypocretin ... See more keywords
The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac039
Abstract: Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due to loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been created to model this disorder… read more here.
Keywords: development; hypocretin orexin; orexin; dta mice ... See more keywords
Effects of sodium oxybate on hypocretin/orexin and locus coeruleus neurons.
Sign Up to like & getrecommendations! Published in 2023 at "Sleep"
DOI: 10.1093/sleep/zsad135
Abstract: Longterm use of sodium oxybate (SXB), (also called gamma-hydroxybutyrate (GHB)) attenuates the cataplexy and sleepiness of human narcolepsy. We had previously found that chronic opiate usage in humans and longterm opiate administration to mice significantly… read more here.
Keywords: sodium oxybate; hypocretin orexin; locus coeruleus; sxb ... See more keywords
Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of neurology and neuroscience"
DOI: 10.1159/000514959
Abstract: Since its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset in the disorder, a gateway… read more here.
Keywords: hypocretin orexin; rem sleep; orexin deficiency; role hypocretin ... See more keywords
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of neurology and neuroscience"
DOI: 10.1159/000514963
Abstract: The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G-protein-coupled receptors, HCRTR1/OX1R and HCRTR2/OX2R. Shortly after the discovery of this system, degeneration… read more here.
Keywords: hypocretin orexin; pharmacology; orexin receptor; receptor pharmacology ... See more keywords
Hypocretin/Orexin, Sleep and Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers of neurology and neuroscience"
DOI: 10.1159/000514967
Abstract: Advances in translational research provide key opportunities to explore the physiological and pathological effects of sleep in different neurodegenerative diseases. Recent findings suggest that sleep-wakefulness dysfunctions may predispose to neurodegenerative disorders such as Alzheimer's disease… read more here.
Keywords: hypocretin orexin; wakefulness; orexin sleep; alzheimer disease ... See more keywords
Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178573
Abstract: The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified… read more here.
Keywords: hypocretin orexin; hcrt; number; size ... See more keywords