Is it required to routinely check fibrinogen level in patients with rheumatic diseases on tocilizumab? Case-based review
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DOI: 10.1007/s00296-019-04268-x
Abstract: Tocilizumab (TCZ) may rarely cause hematological side effects including neutropenia and thrombocytopenia. TCZ is essentially expected to lower the fibrinogen levels to stay within the normal range, but TCZ-induced hypofibrinogenemia has been rarely reported in… read more here.
Keywords: fibrinogen; tcz; routinely check; review ... See more keywords
Analysis of the clinical characteristics of tigecycline-induced hypofibrinogenemia.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2022.2105488
Abstract: Knowledge regarding the association between hypofibrinogenemia and tigecycline is based mainly on case reports. However, the clinical features of tigecycline-induced hypofibrinogenemia are unclear. We collected 20 patients (16 males and 4 females) with tigecycline-induced hypofibrinogenemia… read more here.
Keywords: fibrinogen levels; induced hypofibrinogenemia; analysis clinical; hypofibrinogenemia ... See more keywords
Role of Fibrinogen in Trauma-Induced Coagulopathy.
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DOI: 10.1097/xcs.0000000000000078
Abstract: BACKGROUND Fibrinogen is the first coagulation factor to decrease after massive hemorrhage. European massive transfusion guidelines recommend early repletion of fibrinogen; however, this practice has not been widely adopted in the US. We hypothesize that… read more here.
Keywords: role fibrinogen; trauma induced; induced coagulopathy; fibrinogen ... See more keywords
Incidence, characteristics and risk factors of hypofibrinogenemia associated with tigecycline: A multicenter retrospective study in China
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DOI: 10.3389/fphar.2022.943674
Abstract: Background: Tigecycline was recently found to cause coagulation disorders, especially hypofibrinogenemia, which may interfere with the administration of antimicrobial therapy. This study aimed to investigate the incidence and clinical characteristics of and risk factors for… read more here.
Keywords: incidence; characteristics risk; risk factors; hypofibrinogenemia ... See more keywords
Early administration of fibrinogen concentrate in patients with polytrauma with thromboelastometry suggestive of hypofibrinogenemia: A randomized feasibility trial
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DOI: 10.6061/clinics/2021/e3168
Abstract: OBJECTIVE: To evaluate the clinical effects of early administration of fibrinogen concentrate in patients with severe trauma and hypofibrinogenemia. METHODS: We conducted an open randomized feasibility trial between December 2015 and January 2017 in patients… read more here.
Keywords: fibrinogen concentrate; group; concentrate; feasibility ... See more keywords